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130909s2013 ne | s |||| 0|eng d |
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|a 9789400771499
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| 024 |
7 |
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|a 10.1007/978-94-007-7149-9
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Prostate Cancer: Shifting from Morphology to Biology /
|c edited by Stefania Staibano.
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| 250 |
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|a 1st ed. 2013.
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| 260 |
# |
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|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a XVIII, 296 p. 41 illus., 38 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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|a Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases -- II Molecular pathology -- Molecular determinants of cancer-related inflammation -- Apoptosis and autophagy -- Androgen receptor and steroidogenesis pathways -- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy -- Metastatic dissemination -- Resistance to castration - resistance to drugs -- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer -- Gene polymorphisms -- Expression signature -- Mapping prostate cancer aggressiveness loci -- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models -- Targeting tumor angiogenesis -- Efficacy of signal transduction inhibition in advanced prostate cancer -- Therapeutic targeting of the bone pre-metastatic niche -- Counteracting hypoxia in radio-resistant metastatic lesions -- “Synthetic lethality”: molecular co-targeting to restore the DNA -- Repair mechanisms in prostate cancer cells concluding remarks. Index.
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| 650 |
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|a Cancer research.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Gene expression.
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| 650 |
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|a Drug resistance.
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| 650 |
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|a Pathology.
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| 650 |
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|a Oncology .
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| 650 |
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4 |
|a Cancer Research.
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| 650 |
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4 |
|a Human Genetics.
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| 650 |
2 |
4 |
|a Gene Expression.
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| 650 |
2 |
4 |
|a Drug Resistance.
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| 650 |
2 |
4 |
|a Pathology.
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| 650 |
2 |
4 |
|a Oncology.
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| 700 |
1 |
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|a Staibano, Stefania.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|