Prostate Cancer: Shifting from Morphology to Biology /
| Autor Corporativo: | |
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| Otros Autores: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2013.
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| Edición: | 1st ed. 2013. |
| Materias: |
Tabla de Contenidos:
- Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases
- II Molecular pathology
- Molecular determinants of cancer-related inflammation
- Apoptosis and autophagy
- Androgen receptor and steroidogenesis pathways
- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy
- Metastatic dissemination
- Resistance to castration - resistance to drugs
- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer
- Gene polymorphisms
- Expression signature
- Mapping prostate cancer aggressiveness loci
- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models
- Targeting tumor angiogenesis
- Efficacy of signal transduction inhibition in advanced prostate cancer
- Therapeutic targeting of the bone pre-metastatic niche
- Counteracting hypoxia in radio-resistant metastatic lesions
- “Synthetic lethality”: molecular co-targeting to restore the DNA
- Repair mechanisms in prostate cancer cells concluding remarks. Index.