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03070nam a22003975i 4500 |
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20210908152844.0 |
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cr nn 008mamaa |
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170315s2017 si | s |||| 0|eng d |
| 020 |
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|a 9789811032332
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| 024 |
7 |
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|a 10.1007/978-981-10-3233-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a RUNX Proteins in Development and Cancer /
|c edited by Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen.
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| 250 |
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|a 1st ed. 2017.
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| 260 |
# |
# |
|a Singapore :
|b Springer Singapore :
|b Imprint: Springer,
|c 2017.
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| 300 |
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|a XX, 515 p. 98 illus., 92 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in Experimental Medicine and Biology,
|v 962
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| 505 |
0 |
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|a RUNX in invertebrates -- Structure and biophysics of CBFb/RUNX and its transcription products -- Covalent modification of RUNX proteins: structure affects function -- The role of Runx1 in embryonic blood cell formation -- RUNX1 structure and function in blood cell development -- Roles of Runx2 in skeletal development -- Roles of Runx genes in nervous system development -- Runx family genes in tissue stem cell dynamics -- Roles of RUNX1 enhancer in normal hematopoiesis and leukemogenesis -- RUNX1-ETO leukemia -- Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders -- Mechanism of ETV6-RUNX1 leukemia -- ETV6-RUNX1+ acute lymphoblastic leukemia in identical twins -- Molecular basis and targeted inhibition of CBFb-SMMHC acute myeloid leukemia -- The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models -- RUNX1 and CBFb mutations and activities of their wild-type alleles in AML -- Roles of RUNX in B cell immortalization -- Roles of RUNX in solid tumors -- RUNX3 and p53: How two tumor suppressors cooperate against oncogenic Ras -- Runx3 and cell fate decisions in pancreas cancer -- RUNX genes in breast cancer and the mammary lineage -- Runx3 in immunity, inflammation and cancer -- Roles of RUNX complexes in immune cell development -- CBFb and HIV infection -- Roles of RUNX in Hippo pathway signaling -- Roles of RUNX in hypoxia-induced responses and angiogenesis -- The emerging roles of RUNX transcription factors in Epithelial-Mesenchymal Transition -- Regulatory role of RUNX1 and RUNX3 in the maintenance of genomic integrity.
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| 650 |
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0 |
|a Medical genetics.
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| 650 |
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0 |
|a Oncology .
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| 650 |
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0 |
|a Proteins .
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| 650 |
1 |
4 |
|a Gene Function.
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| 650 |
2 |
4 |
|a Oncology.
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| 650 |
2 |
4 |
|a Protein Science.
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| 700 |
1 |
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|a Groner, Yoram.
|e editor.
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| 700 |
1 |
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|a Ito, Yoshiaki.
|e editor.
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| 700 |
1 |
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|a Liu, Paul.
|e editor.
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| 700 |
1 |
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|a Neil, James C.
|e editor.
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| 700 |
1 |
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|a Speck, Nancy A.
|e editor.
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| 700 |
1 |
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|a van Wijnen, Andre.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|