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170814s2017 xxu| s |||| 0|eng d |
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|a 9781493972012
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| 024 |
7 |
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|a 10.1007/978-1-4939-7201-2
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Proteomics for Drug Discovery :
|b Methods and Protocols /
|c edited by Iulia M. Lazar, Maria Kontoyianni, Alexandru C. Lazar.
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| 250 |
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|a 1st ed. 2017.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2017.
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| 300 |
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|a XI, 302 p. 62 illus., 46 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1647
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| 505 |
0 |
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|a A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates -- Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins -- Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics -- High Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators -- Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery -- Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules -- Microfluidics-Mass Spectrometry of Protein-Carbohydrate Interactions: Applications to Development of Therapeutics and Biomarker Discovery -- Studying Protein-Protein Interactions by Biotin AP-Tagged Pulldown and LTQ-Orbitrap Mass Spectrometry -- Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation -- Reverse Phase Protein Arrays and Drug Discovery -- Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog -- Preparation of Disease-Related Protein Assemblies for Single Particle Electron Microscopy -- Identification of Lipid-Binding Modulators Using the Protein-Lipid Overlay Assay -- Resazurin Live Cell Assay: Setup and Fine-Tuning for Reliable Cytotoxicity -- Exploring Protein-Protein Interactions as Drug Targets for Anti-Cancer Therapy with In Silico Workflows -- Method to Identify Silent Codon Mutations that May Alter Peptide Elongation Kinetics and Co-Translational Protein Folding -- In Silico Design of Anticancer Peptides -- Docking and Virtual Screening in Drug Discovery -- Bioinformatics Resources for Interpreting Proteomics Mass Spectrometry Data.
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| 650 |
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0 |
|a Pharmacology.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 700 |
1 |
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|a Lazar, Iulia M.
|e editor.
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| 700 |
1 |
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|a Kontoyianni, Maria.
|e editor.
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| 700 |
1 |
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|a Lazar, Alexandru C.
|e editor.
|
| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|