Protein Misfolding and Cellular Stress in Disease and Aging : Concepts and Protocols /
| Autor Corporativo: | |
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| Otros Autores: | , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2010.
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| Edición: | 1st ed. 2010. |
| Colección: | Methods in Molecular Biology,
648 |
| Materias: |
Tabla de Contenidos:
- Concepts
- Protein Misfolding and Cellular Stress: An Overview
- Protein Aggregation Diseases: Toxicity of Soluble Prefibrillar Aggregates and Their Clinical Significance
- Consequences of Stress in the Secretary Pathway: The ER Stress Response and Its Role in the Metabolic Syndrome
- What Role Does Mitochondrial Stress Play in Neurodegenerative Diseases?
- Autophagy in Disease
- Mitophagy and Mitoptosis in Disease Processes
- Cellular Stress and Protein Misfolding During Aging
- Measuring Consequences of Protein Misfolding and Cellular Stress Using OMICS Techniques
- Protocols
- Production of Cells with Targeted Integration of Gene Variants of Human ABC Transporter for Stable and Regulated Expression Using the Flp Recombinase System
- Stress Response Profiles in Human Fibroblasts Exposed to Heat Shock or Oxidative Stress
- Examining Ubiquitinated Protein Aggregates in Tissue Sections
- Determination of Proteasomal Activities
- Measurement of Autophagy in Cells and Tissues
- Transcription Factor Sequestration by Polyglutamine Proteins
- Biological Membranes as Protein Aggregation Matrices and Targets of Amyloid Toxicity
- Measurement of Mitochondrial ROS Production
- In Vivo Detection of Oxidized Proteins: A Practical Approach to Tissue-Derived Mitochondria
- Measurement of Oxidized/Reduced Glutathione Ratio
- Determination of Altered Mitochondria Ultrastructure by Electron Microscopy
- Assessing Bad Sub-cellular Localization Under Conditions Associated with Prevention or Promotion of Mitochondrial Permeability Transition-Dependent Toxicity
- A Cellular Viability Assay to Monitor Drug Toxicity
- Rescue of Misfolded Proteins and Stabilization by Small Molecules.