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140908s2014 ne | s |||| 0|eng d |
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|a 9789401792110
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| 024 |
7 |
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|a 10.1007/978-94-017-9211-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Mutant p53 and MDM2 in Cancer /
|c edited by Swati Palit Deb, Sumitra Deb.
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| 250 |
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|a 1st ed. 2014.
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| 260 |
# |
# |
|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 2014.
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| 300 |
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|a VIII, 373 p. 38 illus., 36 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Subcellular Biochemistry,
|v 85
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| 505 |
0 |
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|a p53 and hereditary cancer.- Alterations of p63 and p73 in human cancers.- Cooperation of p53 mutations with other oncogenic alterations in cancer -- p53 mutations and how mutations affect transcription.- Transcriptional regulation by mutant p53 and oncogenesis -- p53 mutation in the genesis of metastasis -- Structural studies on mechanisms to activate mutant p53 -- Mutant p53 and the response to chemotherapy and radiation -- The p53-MDM2 loop: a critical juncture of stress response -- Mechanisms of mutant p53 stabilization in cancer -- Crosstalk between Mdm2, p53 and HIF-1α: distinct responses to oxygen stress and implications for tumour hypoxia -- MDM2 overexpression, activation of signaling networks, and cell proliferation -- p53-independent effects of MDM2 -- Splice variants of MDM2 in oncogenesis -- MDM2 and MDMX involvement in human cancer -- Targeting the p53-MDM2- MDMX loop for cancer therapy -- Involvement of p53 in the repair of DNA double strand breaks: Multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ) -- The role of tumor suppressor p53 in the antioxidant defense and metabolism -- Lung cancer stem cells, p53 mutations and MDM2.
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| 650 |
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0 |
|a Cancer research.
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| 650 |
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0 |
|a Cell biology.
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| 650 |
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|a Oncology .
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| 650 |
1 |
4 |
|a Cancer Research.
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| 650 |
2 |
4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Oncology.
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| 700 |
1 |
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|a Deb, Swati Palit.
|e editor.
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| 700 |
1 |
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|a Deb, Sumitra.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|