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02865nam a22003255i 4500 |
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20210607093627.0 |
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cr nn 008mamaa |
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131206s2014 xxu| s |||| 0|eng d |
| 020 |
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|a 9781627037303
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| 024 |
7 |
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|a 10.1007/978-1-62703-730-3
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Therapeutic Applications of Ribozymes and Riboswitches :
|b Methods and Protocols /
|c edited by Daniel Lafontaine, Audrey Dubé.
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| 250 |
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|a 1st ed. 2014.
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| 260 |
# |
# |
|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2014.
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| 300 |
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|a XI, 278 p. 53 illus., 19 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1103
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| 505 |
0 |
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|a Identification of Regulatory RNA in Bacterial Genomes by Genome-Scale Mapping of Transcription Start Sites -- Screening Inhibitory potential of anti-HIV RT RNA Aptamers -- Design and Evaluation of Clinically Relevant SOFA-HDV Ribozymes Targeting HIV RNA -- Directing RNase P-mediated Cleavage of Target mRNAs by Engineered External Guide Sequences in Cultured Cells -- Design and Analysis of Hammerhead Ribozyme Activity Against an Artificial Gene Target -- Knockdown Strategies for the Study of Proprotein Converstase and Proliferation in Prostate Cancer Cells -- Use of Tumor-Targeting Trans-Splicing Ribozyme for Cancer Treatment -- Characterization of Hairpin Ribozyme Reactions -- Finding Instances of Riboswitches and Ribozymes by Homology Search of Structured RNA with Infernal -- Structure-based Virtual Screening for the Identification of RNA-binding Ligands -- Probing Riboswitch Binding Sites with Molecular Docking, Focused Libraries, and in-line Probing Assays -- Discovery of Small Molecule Modifiers of microRNAs for the Treatment of HCV Infection -- Bacterial Flavin Mononucleotide Riboswitches as Targets for Flavin Analogs -- Construction and Application of Riboswitch-based Sensors That Detect Metabolites Within Bacterial Cells -- Screening Assays to Identify Artificial glmS Ribozyme Activators -- Analysis of Riboswitch Structure and Ligand Binding using Small-angle X-ray Scattering (SAXS) -- Use of SHAPE to Select 2AP Substitution sites for RNA-ligand Interactions and Dynamics Studies -- Cell Internalization SELEX: In Vitro Selection for Molecules that Internalize into Cells -- DNA Electronic Switches Based on Analyte-Responsive Aptamers.
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| 650 |
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0 |
|a Pharmacology.
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| 650 |
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0 |
|a Human genetics.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Human Genetics.
|
| 700 |
1 |
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|a Lafontaine, Daniel.
|e editor.
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| 700 |
1 |
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|a Dubé, Audrey.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|