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171129s2018 xxu| s |||| 0|eng d |
| 020 |
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|a 9781493975228
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| 024 |
7 |
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|a 10.1007/978-1-4939-7522-8
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Retinal Gene Therapy :
|b Methods and Protocols /
|c edited by Camiel J.F. Boon, Jan Wijnholds.
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| 250 |
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|a 1st ed. 2018.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2018.
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| 300 |
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|a XVI, 380 p. 54 illus., 44 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1715
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| 505 |
0 |
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|a Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System -- Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications -- Design and Development of AAV-Based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa -- Development of Multigenic Lentiviral Vectors for Cell-Specific Expression of Antiangiogenic miRNAs and Protein Factors -- Design and In Vitro Use of Antisense Oligonucleotides to Correct Pre-mRNA Splicing Defects in Inherited Retinal Dystrophies -- Three-Dimensional Co-Culture Bioassay for Screening of Retinal Gene Delivery Systems -- Retinal Gene Therapy for Choroideremia: In Vitro Testing for Gene Augmentation Using an Adeno-Associated Viral (AAV) Vector -- In Vivo Electroporation of Developing Mouse Retina -- Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina -- AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa -- Dual AAV Vectors for Stargardt Disease -- Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin -- CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa: A Brief Methodology -- In-Depth Functional Analysis of Rodents by Full-Field Electroretinography -- Advanced Ocular Injection Techniques for Therapy Approaches -- Neutralizing Antibodies Against Adeno-Associated Virus (AAV): Measurement and Influence on Retinal Gene Delivery -- Screening for Neutralizing Antibodies against Natural and Engineered AAV Capsids in Non-Human Primate Retinas -- Subretinal and Intravitreal Retinal Injections in Monkeys -- Production of iPS-derived Human Retinal Organoids for Use in Transgene Expression Assays -- AAV Serotype Testing on Cultured Human Donor Retinal Explants -- Human Retinal Explant Culture for Ex-Vivo Validation of AAV Gene Therapy -- Visual Acuity Testing Before and After Intravitreal Injection of rAAV2- ND4 in Patients -- Recording and Analysis of the Human Clinical Electroretinogram -- Recording and Analysis of Goldmann Kinetic Visual Fields -- Measuring Central Retinal Sensitivity Using Microperimetry -- Inspection of the Human Retina by Optical Coherence Tomography -- Vector Shedding and Immunogenicity Sampling for Retinal Gene Therapy.
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| 650 |
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|a Human genetics.
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| 650 |
1 |
4 |
|a Human Genetics.
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| 700 |
1 |
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|a Boon, Camiel J.F.
|e editor.
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| 700 |
1 |
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|a Wijnholds, Jan.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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