The Hsp60 Chaperonin /
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| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2015.
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| Edition: | 1st ed. 2015. |
| Series: | Protein Folding and Structure,
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| Subjects: |
Table of Contents:
- Introduction
- Historical sketch of the discovery and recognition of the function of chaperonins
- Molecular structure of chaperonins
- Folding by enclosure in the chaperonin cavity
- Evolutionary origins and family relations
- Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers?
- Sequence variations in proteins affecting chaperonin dependence
- Genetic organization of type I chaperonin genes
- Regulation of type I chaperonin gene expression
- Subcellular localization
- Posttranslational modifications
- Variations in Hsp60 and Hsp10 in humans
- Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes
- Human diseases caused by genetic mutations in the Hsp60/Hsp10 system
- Molecular investigations of disease mechanisms
- Molecular investigations of disease mechanisms
- Outlook.