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110825s1996 xxu| s |||| 0|eng d |
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|a 9781461303190
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|a 10.1007/978-1-4613-0319-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Subtilisin Enzymes :
|b Practical Protein Engineering /
|c edited by Richard Bott, Christian Betzel.
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| 246 |
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|a Proceedings of an international symposium held in Hamburg, Germany, September 24-26, 1992.
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| 250 |
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|a 1st ed. 1996.
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| 260 |
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|a New York, NY :
|b Springer US :
|b Imprint: Springer,
|c 1996.
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| 300 |
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|a XI, 288 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Advances in Experimental Medicine and Biology,
|v 379
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|a I. Structural Studies of Subtilisin Enzymes Alone and in Complex with Inhibitors -- 1. The Complex between Mesentericopeptidase and Eglin-C -- 2. Crystallographic Study of Eglin-C Binding to Thermitase -- 3. Design of Specific Peptide Structures and Subtilisin Enzyme Inhibitors Using ?, ß-Dehydro-Residues -- 4. Structure and Function of Subtilisin BPN' as Studied through Crystallographic Studies on a Series of Its Complexes with Genetically Engineered Proteinaceous Inhibitor SSI -- 5. Three Dimensional Structure of the Antibiotic Bacitracin A Complexed to Two Different Subtilisin Proteases: Novel Mode of Enzyme Inhibition -- 6. Active Site Binding Loop Stabilization in the Subtilisin Inhibitor Eglin C: Structural and Functional Studies on Specifically Designed Mutants in Complex with Subtilisin and the Uncomplexed Inhibitor -- 7. Crystal Strucutures of the Alkaline Proteases Savinase and Esperase from Bacillus lentus -- II. New Enzymes -- 8. Modelling and Engineering of Enzyme/Substrate Interactions in Subtilisin-like Enzymes of Unknown 3-Dimensional Structure -- 9. Substilases: Subtilisin-like Serine Proteases -- 10. Cloning and Expression of the Gene Encoding a Novel Proteinase from Tritirachium album Limber -- III. Structure-Function Studies -- 11. Studies of Binding Sites in the Subtilisin from Bacillus lentus by Means of Site Directed Mutagenesis and Kinetic Investigations -- 12. Laundry Performance of Subtilisin Proteases -- 13. Free Energy Perturbation Techniques Applied to Subtilisin BPN' Stability -- IV. Biophysical Probes and Mutagenesis -- 14. Thermitase-Kinetic Differentiation to the Subtilisins -- 15. Fluorescence Decay of Tryptophans in Serine Proteinases from Microorganisms: Relation to X-Ray Models -- 16. Propeptide-Mediated Folding in Subtilisin: The Intramolecular Chaperone Concept -- 17. Roles of the N- and C-Terminal Pro-Sequences of Aqualysin I Precursor in the Processing and Extracellular Secretion of the Enzyme -- 18. Crystal Structure Analysis of Subtilisin BPN' Mutants Engineered for Studying Thermal Stability -- 19. Random Mutagenesis of the Weak Calcium Binding Site in Subtilisin Carlsberg and Screening for Thermostability by Temperature-Gradient Gel Electrophoresis -- 20. Inhibition of Proteinase K by Mercury -- V. Protein Engineering of Subtilisin Enzymes -- 21. Crystallographic Investigations of Subtilisin BPN' Mutants Engineered for Studying Thermal Stability -- 22. Structural and Functional Consequences of Engineering the High Alkaline Serine Protease PB92 -- 23. Engineering Surface Charges in a Subtilisin -- 24. pH Dependence of the Catalytic Activity of a Subtilisin-like Proteinase -- 25. An Investigation of the Savinase Water Channel: Implications of Cavity Mutations -- 26. Substrate Specificity of Natural Variants and Genetically Engineered Intermediates of Bacillus lentus Alkaline Proteases -- 27. Unusual Ligand Binding at the Active Site Domain of an Engineered Mutant of Subtilisin BL -- 28. Studies on the Structure and Function of Subtilisin E by Protein Engineering -- 29. Structural Changes Leading to Increased Enzymatic Activity in an Engineered Variant of Bacillus lentus Subtilisin.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Animal anatomy.
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| 650 |
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|a Plant science.
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| 650 |
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|a Botany.
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| 650 |
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|a Biophysics.
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| 650 |
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|a Biological physics.
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| 650 |
1 |
4 |
|a Human Genetics.
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| 650 |
2 |
4 |
|a Animal Anatomy / Morphology / Histology.
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| 650 |
2 |
4 |
|a Plant Sciences.
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| 650 |
2 |
4 |
|a Biological and Medical Physics, Biophysics.
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| 700 |
1 |
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|a Bott, Richard.
|e editor.
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| 700 |
1 |
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|a Betzel, Christian.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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