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170912s2017 gw | s |||| 0|eng d |
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|a 9783319577326
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| 024 |
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|a 10.1007/978-3-319-57732-6
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Store-Operated Ca²⁺ Entry (SOCE) Pathways :
|b Emerging Signaling Concepts in Human (Patho)physiology /
|c edited by Klaus Groschner, Wolfgang F. Graier, Christoph Romanin.
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| 250 |
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|a 2nd ed. 2017.
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| 260 |
# |
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2017.
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| 300 |
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|a XXIX, 645 p. 84 illus., 62 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in Experimental Medicine and Biology,
|v 993
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| 505 |
0 |
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|a Part 1. SOCE - Fundamental Mechanistic Concepts -- 1. Introduction -- 2. STIM/Orai Structures: Isolated and in Complex -- 3. Orai, the Pore-Forming Subunit of the CRAC Channel -- 4. The Interactions between STIM and Orai -- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry -- 6. Regulation of STIM and Orai by Thiol Modifications -- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels -- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes -- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function -- 10. Auxiliary Proteins of the STIM/Orai Complex -- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments -- 11. Introduction -- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE -- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores -- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+ Entry and Mitochondria -- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry -- 16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry -- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling -- 18. Tissue specificity SOCE - Implications for Ca2+ Handling in Endothelial Cells -- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes -- Part 3. SOCE - Molecular and Cellular (Patho) Physiology -- 20. Introduction -- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes -- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders -- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction -- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells - Emerging Targets for Therapeutic Intervention -- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology -- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology -- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function -- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle -- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation -- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease -- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.
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| 650 |
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|a Cell biology.
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| 650 |
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|a Medical biochemistry.
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| 650 |
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|a Biophysics.
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| 650 |
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|a Biological physics.
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| 650 |
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|a Cardiology.
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| 650 |
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4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Medical Biochemistry.
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| 650 |
2 |
4 |
|a Biological and Medical Physics, Biophysics.
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| 650 |
2 |
4 |
|a Cardiology.
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| 700 |
1 |
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|a Groschner, Klaus.
|e editor.
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| 700 |
1 |
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|a Graier, Wolfgang F.
|e editor.
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| 700 |
1 |
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|a Romanin, Christoph.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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