Store-Operated Ca²⁺ Entry (SOCE) Pathways : Emerging Signaling Concepts in Human (Patho)physiology /
| Corporate Author: | |
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| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2017.
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| Edition: | 2nd ed. 2017. |
| Series: | Advances in Experimental Medicine and Biology,
993 |
| Subjects: |
Table of Contents:
- Part 1. SOCE - Fundamental Mechanistic Concepts
- 1. Introduction
- 2. STIM/Orai Structures: Isolated and in Complex
- 3. Orai, the Pore-Forming Subunit of the CRAC Channel
- 4. The Interactions between STIM and Orai
- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry
- 6. Regulation of STIM and Orai by Thiol Modifications
- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels
- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
- 10. Auxiliary Proteins of the STIM/Orai Complex
- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments
- 11. Introduction
- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+ Entry and Mitochondria
- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry
- 16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry
- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
- 18. Tissue specificity SOCE - Implications for Ca2+ Handling in Endothelial Cells
- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes
- Part 3. SOCE - Molecular and Cellular (Patho) Physiology
- 20. Introduction
- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes
- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders
- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction
- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells - Emerging Targets for Therapeutic Intervention
- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology
- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function
- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle
- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation
- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease
- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.