Structure-Based Drug Discovery /
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2012.
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| Edition: | 1st ed. 2012. |
| Series: | Methods in Molecular Biology,
841 |
| Subjects: |
Table of Contents:
- The Utility of Structural Biology in Drug Discovery
- Genetic Construct Design and Recombinant Protein Expression for Structural Biology
- Purification of Proteins for Crystallographic Applications
- Protein Crystallization for Structure-Based Drug Design
- X-Ray Sources and High-Throughput Data Collection Methods
- The Use of Molecular Graphics in Structure-Based Drug Design
- Crystallographic Fragment Screening
- The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase
- Leveraging Structural Information for the Discovery of New Drugs: Computational Methods
- Chemical Informatics - Using Molecular Shape Descriptors in Structure-Based Drug Design
- Accounting for Solvent in Structure-Based Drug Design
- Structure-Based Drug Design on Membrane Protein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein
- Application of SBDD to the Discovery of New Antibacterial Drugs
- Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering
- A Medicinal Chemistry Perspective on Structure-Based Drug Design and Development.