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141013s2014 ne | s |||| 0|eng d |
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|a 9789401790789
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|a 10.1007/978-94-017-9078-9
|2 doi
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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|a Translation and Its Regulation in Cancer Biology and Medicine /
|c edited by Armen Parsyan.
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| 250 |
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|a 1st ed. 2014.
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| 260 |
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|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 2014.
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| 300 |
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|a XXXIV, 697 p. 52 illus., 44 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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|a Preface -- Introduction -- PART I. TRANSALATION MACHINERY IN CANCER -- Mechanism of Translation in Eukaryotes -- Diverse Mechanisms of Translation Regulation and Their Role in Cancer -- eIF4E and Its Binding Proteins -- RNA Helicases and Their Cofactors -- PDCD4 -- eIF4G -- eIF3 -- The eIF2 Complex and eIF2α -- eIF5A -- eIF6 -- Translation Elongation -- Ribosomes -- Current and Emerging Therapies Targeting Translation -- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER -- mTOR and Regulation of Translation -- Ribosomal Protein S6 and S6 Kinases -- eIF4E Phosphorylation Downstream of MAPK Pathway -- PART III. CELL FATE AND TRANSLATION IN CANCER -- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells -- Translation and Apoptosis in Cancer -- Translation in Cancer at Hypoxia -- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES -- Melanoma and Non-Melanoma Skin Cancers -- Sarcomas -- Hematological Malignancies and Premalignant Conditions -- Brain Tumors -- Head and Neck Cancers -- Breast Cancer -- Cancers of the Respiratory System -- Gastric and Esophageal Cancers -- Colorectal Cancers -- Hepatic, Pancreatic and Biliary Cancers -- Pancreatic Neuroendocrine Tumors -- Gynecologic Cancers -- Prostate Cancer -- Cancers of the Urinary System -- List of Abbreviations.
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| 650 |
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|a Cancer research.
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| 650 |
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|a Oncology .
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| 650 |
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|a Cell biology.
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Biochemistry.
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| 650 |
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|a Medicine.
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| 650 |
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4 |
|a Cancer Research.
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| 650 |
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|a Oncology.
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| 650 |
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4 |
|a Cell Biology.
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| 650 |
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4 |
|a Molecular Medicine.
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| 650 |
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|a Biochemistry, general.
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| 650 |
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|a Biomedicine, general.
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| 700 |
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|a Parsyan, Armen.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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