Prodrugs Challenges and Rewards /
| Autor Corporativo: | |
|---|---|
| Otros Autores: | , , , , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2007.
|
| Edición: | 1st ed. 2007. |
| Colección: | Biotechnology: Pharmaceutical Aspects ;
V |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-0-387-49785-3 |
Tabla de Contenidos:
- A Case for Prodrugs
- A Case for Prodrugs
- Problems Addressable by Prodrugs
- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs
- Topical Delivery Using Prodrugs
- Prodrug approaches to ophthalmic drug delivery
- Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery
- Prodrugs and Parenteral Drug Delivery
- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics
- Prodrugs to Reduce Presystemic Metabolism
- Controlled Release — Small Molecules
- Controlled Release - Macromolecular Prodrugs
- Controlled Release - Proenzymes
- Targeting - Theoretical and Computational Models
- Targeting - Cancer — Small Molecules
- Monoclonal Antibody Drug Conjugates for Cancer Therapy
- Antibody-Directed Enzyme Prodrug Therapy
- Prodrugs for Liver-targeted Drug Delivery
- Prodrug Approaches for Drug Delivery to the Brain
- Lymphatic Absorption of Orally Administered Prodrugs
- Colonic Delivery
- Functional Group Approach to Prodrugs
- Prodrugs of Carboxylic Acids
- Prodrugs of Alcohols and Phenols
- Prodrugs of Amines
- Prodrugs of Amides, Imides and Other NH-acidic Compounds
- Prodrugs of Benzamidines
- Prodrugs of Phosphonates, Phosphinates, and Phosphates
- Functional Group Approaches to Prodrugs: Functional Groups in Peptides
- Macromolecular Prodrugs of Small Molecules
- Miscellaneous Functional Groups
- Prodrugs — Preclinical and Clinical Considerations
- Prodrugs: Absorption, Distribution, Metabolism, Excretion (ADME) Issues
- Formulation Challenges of Prodrugs
- Safety Assessment of Prodrugs
- Toxicological Issues with Pivalate Prodrugs
- Case Studies
- Case Study: Adefovir Dipivoxil: An Oral Prodrug of Adefovir
- Case Study: Amifostine: (Ethyol®)
- Case Study: Capecitabine: A Prodrug of 5-Fluorouracil
- Case Study: Cefditoren Pivoxil: An Oral Prodrug of Cefditoren
- Case Study: Cefuroxime Axetil: An Oral Prodrug of Cefuroxime
- Case Study: Clindamycin 2-Phosphate, A Prodrug of Clindamycin
- Case Study: Enalapril: A Prodrug of Enalaprilat
- Case Study: Famciclovir: A Prodrug of Penciclovir
- Case Study: Fosamprenavir: A Prodrug of Amprenavir
- Case Study: Fosinopril
- Case Study: Fosphenytoin: A Prodrug of Phenytoin
- Case Study: Irinotecan (CPT-11), A Water-soluble Prodrug of SN-38
- Case Study: Latanoprost: Isopropylester of a Prostaglandin F2? Analog
- Case Study: Moexipril Hydrochloride: A Prodrug of Moexiprilat
- Case Study: Mycophenolate Mofetil
- Case Study: Olmesartan Medoxomil: A Prodrug of Olmesartan
- Case Study: Omeprazole (Prilosec®)
- Case Study: Oseltamivir: An Orally Bioavailable Ester Prodrug of Oseltamivir Carboxylate
- Case Study: Parecoxib: A Prodrug of Valdecoxib
- Case Study: Tenofovir Disoproxil Fumarate: An Oral Prodrug of Tenofovir
- Case Study: Travoprost: A Potent PGF2? Analog
- Case Study: Valacyclovir: A Prodrug of Acyclovir
- Case Study: Valganciclovir: A Prodrug of Ganciclovir
- Case Study: Vantin: A Prodrug of Cefpodoxime
- Case Study: Ximelagatran: A Double Prodrug of Melagatran.