The Kinetochore: From Molecular Discoveries to Cancer Therapy /

Bibliographic Details
Corporate Author:	SpringerLink (Online service)
Other Authors:	De Wulf, Peter. (Editor), Earnshaw, William. (Editor)
Format:	eBook
Language:	English
Published:	New York, NY : Springer New York : Imprint: Springer, 2009.
Edition:	1st ed. 2009.
Subjects:	Cancer research. Cell biology. Medical microbiology. Molecular biology. Human genetics. Virology. Cancer Research. Cell Biology. Medical Microbiology. Molecular Medicine. Human Genetics.
Online Access:	https://doi.org/10.1007/978-0-387-69076-6

Table of Contents:

Centromeres and Kinetochores: An Historical Perspective
The Basics of Chromosome Segregation
The Centromere
Neocentromeres
Human Artificial Centromeres: Assembly of Functional Centromeres on Human Artificial Chromosomes
Kinetochore Composition, Formation, and Organization
Evolution of Centromeres and Kinetochores: A Two-Part Fugue
Mitotic Spindle Assembly Mechanisms
Kinetochore-Microtubule Interactions
Post-Translational Modifications that Regulate Kinetochore Activity
The Role of the Kinetochore in Spindle Checkpoint Signaling
Kinetochore Regulation of Anaphase and Cytokinesis
Roles of Centromeres and Kinetochores in Meiosis
The Kinetochore-Cancer Connection
The Kinetochore as Target for Cancer Drug Development.

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