Carnitine Today
| Autores principales: | , |
|---|---|
| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer US : Imprint: Springer,
1997.
|
| Edición: | 1st ed. 1997. |
| Colección: | Molecular Biology Intelligence Unit,
|
| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-1-4615-6005-0 |
Tabla de Contenidos:
- 1. The Role of Carnitine in Cell Metabolism
- A Century of Carnitine Research
- Biosynthesis, Uptake and Excretion
- Carnitine Acyltransferases
- Fatty Acid Oxidation in Liver
- Fatty Acid Oxidation in Heart
- Carnitine in Insulin Secretion
- Perspectives
- 2. Molecular Biology of Carnitine Palmitoyltransferases and Role of Carnitine in Gene Transcription
- Mitochondrial CPTs
- Peroxisomal CPTs
- Microsomal CPTs
- Nuclear CPTs
- A Role for Carnitine in the Transcriptional Regulation
- Perspectives
- 3. Carnitine and Myocardial Glucose Metabolism
- Review of the Literature
- Conclusions
- 4. Carnitine and Mitochondrial Dysfunction
- Mitochondrial Function and Dysfunction
- Carnitine-Related Mitochondrial Disorders
- Carnitine, CoA and Mitochondrial Function
- Carnitine and Mitochondrial Alterations Induced by Anoxia
- 5. Effect of L-Carnitine on Fas-Induced Apoptosis and Sphingomyelinase Activity in Human T Cell Lines
- Materials and Methods
- Effect of Camitine on Fas-Induced Apoptosis in Hut78 and U937 Cells
- Effect of L-Carnitine on Fas Crosslinking-Induced Ceramide Generation in Hut78 and U937 Cells
- Effect of L-Carnitine on Fas Crosslinking-Induced Acidic and Neutral SMases
- Effects of L-Carnitine on Purified Acidic and Neutral SMases in Vitro
- Discussion
- 6. Carnitine Deficiency: Primary and Secondary Syndromes
- Carnitine Metabolism
- Functions of Carnitine
- Carnitine Deficiency in Humans
- Primary Carnitine Deficiencies
- Secondary Carnitine Deficiencies
- Myocardial Diseases and Secondary Carnitine Deficiency
- Diabetes and Secondary Carnitine Deficiency
- Idiopathic Inflammatory Myopathies
- Drugs and Carnitine Deficiency
- 7. Carnitine Against Ischemia and Lipopolysaccharide Toxicity
- L-Carnitine in the Treatment of Ischemic Muscles
- Summary
- 8. Carnitine and Derivatives in Experimental Infections
- Results of Murine Studies
- Results of Rat Studies
- Discussion
- 9. Involvement of Carnitine in Reye’s and Reye-Like Syndromes
- Definition of Reye’s and Reye-Like Syndromes
- Pathological Manifestation of RS and RLS
- Involvement of Carnitine
- Carnitine Treatment in RS and RLS
- 10. Fatigue Syndrome
- Summary
- Acylcarnitine (ACR) Deficiency in CFS
- ACR Metabolism in Mammals
- The Uptake of ACR in the Brain of Rhesus Monkeys and Humans
- Hypothesis: the Role of ACR in the Etiology of CFS
- Acetyl-L-Camitine Treatment for Patients with CFS
- 11. L-Carnitine, a Modulator of Immunometabolic Homeostasis in Subjects Infected with the Human Immunodeficiency Virus
- Immunomodulating Properties of L-Carnitine
- Serum and Cellular Carnitine Deficiency in HIV-Infected Subjects
- Carnitine Deficiency and Mitochondrial Toxicity of Nucleoside Analogs
- Etiology of Carnitine Deficiency in AIDS
- Impact of L-Carnitine Therapy on Lymphocyte Mitogen Responsiveness and Carnitine Cellular Content
- Impact of L-Carnitine Therapy on Lymphocyte Apoptosis, CD4 Cell Decline and HIV Viremia
- Concluding Remarks
- 12. Effect of L-Carnitine on the AZT-Induced Mitochondrial Toxicity: Studies on Human Muscle Cultures
- In Vitro Studies
- In Vivo Studies
- Conclusions
- 13. Possible Anti-Apoptotic Activity of Carnitines on Excitatory Amino Acid-Induced Neurotoxicity
- Glutamate and Cancer
- Glutamate May Mediate Some Neurological Disorders
- Pharmacotherapy for Excitatory Amino Acid-Induced Neurotoxicity.