Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy Molecular Mechanisms and Clinical Applications /
| Autor Corporativo: | |
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| Otros Autores: | , , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2009.
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| Edición: | 1st ed. 2009. |
| Colección: | Cancer Drug Discovery and Development,
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| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-1-60327-459-3 |
Tabla de Contenidos:
- Novel Platinum Analogues, Original Formulations and Other Heavy Metals
- Platinum Compounds: The Culmination of the Era of Cancer Chemotherapy
- Studies on New Platinum Compounds
- Assessment of the In Vivo Antiproliferative Activity of a Novel Platinum Particulate Pharmacophore
- Nanocapsules of Platinum-Based Anticancer Drugs
- The Design and Development of the Tumor-Targeting Nanopolymer Dach Platinum Conjugate AP5346 (Prolindac™)
- In vitro Anti-proliferative Effects of ProLindac™, a Novel Dach-Platinum-Linked Polymer Compound, as a Single Agent and in Combination with Other Anti-cancer Drugs
- Synthesis of Cisplatin Analogues: Cytotoxic Efficacy and Anti-tumour Activity of Bis-Amidine and Bis-Iminoether Pt(II) Complexes
- Ruthenium Drugs for Cancer Chemotherapy: An Ongoing Challenge to Treat Solid Tumours
- X-ray Crystal Structure of a Monofunctional Platinum–DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex
- Osmium Arenes: A New Class of Potential Anti-cancer Agents
- Cellular Transport and Intracellular Trafficking of Platinum Compounds
- Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells
- CTR1 as a Determinant of Platinum Drug Transport
- Regulation of the Export of Platinum-Containing Drugs by the Copper Efflux Transporters ATP7A and ATP7B
- Altered Localization of Transport Proteins Associated with Cisplatin Resistance
- How to Overcome Cisplatin Resistance Through Proton Pump Inhibitors
- Cellular Resistance to Oxaliplatin and Drug Accumulation Defects
- Possible Incorporation of Free N7-Platinated Guanines in DNA by DNA Polymerases, Relevance for the Cisplatin Mechanism of Action
- DNA Damage and Signal Transduction: Recognition/Repair And Cell-Response
- Structural and Mechanistic Studies of Anticancer Platinum Drugs: Uptake, Activation, and the Cellular Response to DNA Binding
- Platinum Drugs and DNA Repair: Lessons from the NCI Panel and Clinical Correlates
- Differences in Conformation and Conformational Dynamics Between Cisplatin and Oxaliplatin DNA Adducts
- Regrowth Resistance: Low-Level Platinum Resistance Mediated by Rapid Recovery from Platinum-Induced Cell-Cycle Arrest
- Targeting Nucleotide Excision Repair as a Mechanism to Increase Cisplatin Efficacy
- CHK2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance
- Modulation of Survival Pathways in Ovarian Carcinoma Cells Resistant to Platinum Compounds
- Paraptotic Cell Death Induced by the Thioxotriazole Copper Complex A0: A New Tool to Kill Apoptosis-Resistant Cancer Cells
- Clinical Applications
- Platinum Compounds and Radiation
- Treating Cisplatin-Resistant Cancer: A Systematic Analysis of Oxaliplatin or Paclitaxel Salvage Chemotherapy
- Platinum Compounds in Lung Cancer: Current Status
- Is Lipoplatinum Monotherapy an Active Alternative in Second Line Treatment of Metastatic Non–Small Cell Lung Cancer? A Phase II Trial
- Combining Platinums in Gastric Cancer
- Oxaliplatin-Based Chemotherapy for Colon Cancer
- First-Line Systemic Chemotherapy with Folfoxiri Followed by Radical Surgical Resection of Metastases for the Treatment of Unresectable Metastatic Colorectal Cancer Patients
- Pre-operative Radio-Chemotherapy of Rectal Cancer: Toxicity and Preliminary Results with the Addition of Weekly Oxaliplatin
- The Role of Platins in Newly Diagnosed Endometrial Cancer
- Platinum Compounds: Key Ingredients in Ovarian Cancer Treatment and Strategies
- Intraperitoneal Chemotherapy: An Important Strategy in Ovarian Cancer Treatment
- Novel Strategies for Enhancing the Efficacy of Intraperitoneal Chemotherapy for Patients with Ovarian Cancer
- Laparoscopically Assisted Heated Intra-Operative Intraperitoneal Chemotherapy (HIPEC): Technical Aspect and Pharmacokinetics Data
- Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity
- Peripheral Neurotoxicity of Platinum Compounds
- Platinum Drugs in Children with Cancer
- Optimising Carboplatin Dose using Patient Characteristics and Therapeutic Drug Monitoring.