Protein-Protein Interactions as New Drug Targets

Protein-Protein Interactions as New Drug Targets

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Klussmann, Enno. (Editor), Scott, John. (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2008.
Edition:1st ed. 2008.
Series:Handbook of Experimental Pharmacology, 186
Subjects:
Pharmacology.
Cell biology.
Medical biochemistry.
Molecular biology.
Pharmacology/Toxicology.
Cell Biology.
Medical Biochemistry.
Molecular Medicine.
Online Access:https://doi.org/10.1007/978-3-540-72843-6
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024 7 |a 10.1007/978-3-540-72843-6  |2 doi 
040 |a Sistema de Bibliotecas del Tecnológico de Costa Rica 
245 1 0 |a Protein-Protein Interactions as New Drug Targets  |c edited by Enno Klussmann, John Scott. 
246 3 |a With contributions by numerous experts 
250 |a 1st ed. 2008. 
260 # # |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg :  |b Imprint: Springer,  |c 2008. 
300 |a XV, 512 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Handbook of Experimental Pharmacology,  |v 186 
505 0 |a Organization of Scaffolds -- A-Kinase Anchoring Proteins as the Basis for cAMP Signaling -- Arrestins as Multi-Functional Signaling Adaptors -- Role of Ena/VASP Proteins in Homeostasis and Disease -- Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy -- Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox? -- Scaffolding Proteins and Cellular Signalling -- PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases -- G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains -- Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design -- Compartmentalised MAPK Pathways -- Dynamic Protein Complexes Regulate NF-?B Signaling -- An Oncogenic Hub: ?-Catenin as a Molecular Target for Cancer Therapeutics -- A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling -- Cell Type-Specific Anchoring -- Scaffolding Proteins in Cardiac Myocytes -- Molecular Architecture of Signal Complexes Regulating Immune Cell Function -- Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework -- Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept -- Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies -- Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition -- Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors -- Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs -- Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets. 
650 0 |a Pharmacology. 
650 0 |a Cell biology. 
650 0 |a Medical biochemistry. 
650 0 |a Molecular biology. 
650 1 4 |a Pharmacology/Toxicology. 
650 2 4 |a Cell Biology. 
650 2 4 |a Medical Biochemistry. 
650 2 4 |a Molecular Medicine. 
700 1 |a Klussmann, Enno.  |e editor. 
700 1 |a Scott, John.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
856 4 0 |u https://doi.org/10.1007/978-3-540-72843-6 

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