Pharmacokinetics An Introduction /
| Autores principales: | , |
|---|---|
| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
1979.
|
| Edición: | 1st ed. 1979. |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-3-642-67188-3 |
Tabla de Contenidos:
- I. Volume of Distribution
- II. Compartments
- 1. Protein Binding
- 2. Gastrointestinal Reabsorption
- III. Elimination
- 1. Equation for Elimination
- IV. Steady State
- 1. Conditions for a Steady State
- 2. Artificial Steady State — Continous Infusion
- V. Multicompartment Systems
- 1. The Model
- 2. Dost’s Principle of Corresponding Areas
- 3. Dost’s Rule of Corresponding Fractional Areas
- 4. General Consideration of Multicompartment Models
- VI. Pharmacokinetics and Treatment
- 1. Repeated Administration of a Drug
- VII. Pharmacokinetics of Gastrointestinal Absorption
- 1. Gastrointestinal Absorption and the Bateman Function
- 2. Reconstruction of the Invasion Curves
- 3. Use of the Invasion Curves
- 4. Calculation of Dose-Proportional Absorption
- 5. Variants of the Invasion Process in Gastrointestinal Absorption
- 6. Conclusions
- 7. Appendix: Some Formulae and Their Derivation
- VIII. Interaction
- 1 Elimination
- 2. Volume of Distribution
- 3. Conclusions
- IX. Use of Analogue Computers in Pharmacokinetics
- 1. Principle of the Analogue Computer
- 2. Programming the Analogue Computer
- 3. Use
- X. Practical Application of Pharmacokinetic Procedures
- 1. Methods of Measurement
- 2. Assessment of the Results of Animal Experiments
- 3. Derivation of Pharmacokinetic Parameters and Constants
- 4. Mathematical Basis of Programming
- 5. Examples of Calculation
- Further Reading.