The Practice of Peptide Synthesis
Autores principales: | , |
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Autor Corporativo: | |
Formato: | eBook |
Lenguaje: | English |
Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
1994.
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Edición: | 2nd ed. 1994. |
Colección: | Springer Lab Manuals
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Materias: | |
Acceso en línea: | https://doi.org/10.1007/978-3-642-85055-4 |
Tabla de Contenidos:
- I Introduction
- II Protecting Groups
- 1 Introduction of Amine Protecting Groups
- 2 Blocking of the ?-Carboxyl Group
- 3 Protection of Side Chain Functions
- III Activation and Coupling
- 1 The Acid Chloride Procedure
- 2 The Azide Process
- 3 Symmetrical Anhydrides
- 4 Mixed Anhydrides
- 5 Preparation of Active Esters
- 6 Coupling with Active Esters
- 7 Peptide Bond Formation with the Aid of Coupling Reagents
- IV Removal of Protecting Groups
- 1 Hydrogenation
- 2 Reduction with Sodium in Liquid Ammonia
- 3 Removal of the Phthalyl (Phthaloyl) Group by Hydrazinolysis
- 4 Acidolysis
- 5 Hydrolysis
- 6 Base Catalyzed Elimination
- 7 Nucleophilic Displacement
- 8 Iodolysis
- 9 Reduction of Methionine Sulfoxide Containing Peptides
- V Special Procedures
- 1 Ammonolysis of Esters
- 2 Transesterification
- 3 Cyclization
- 4 Polycondensation
- 5 Partial Synthesis
- VI Models for the Study of Racemization
- 1 Benzoyl-leucyl-glycine Ethyl Ester
- 2 The Anderson-Callahan Test
- 3 Acylation with Acetyl-l-isoleucine
- 4 The Izumiya-Muraoka Model
- 5 Synthesis and Enantioselective Enzymic Hydrolysis of Tetraalanine
- VII Reagents for Peptide Synthesis
- 1 tert-Butyl Azidoformate
- 2 1-Adamantyl Chlorocarbonate
- 3 1-Isobutyloxycarbonyl-2-isobutyloxy-1,2-dihydroquinoline (IIDQ)
- 4 Diphenyl Phosphorazidate (Diphenylphosphoryl Azide, DPPA)
- 5 3-Hydroxy-3,4-dihydroquinazoline-4-one (4-Hydroxyquinazoline 3-oxide)
- 6 1-Hydroxybenzotriazole
- 7 Ethyl 2-hydroximino-2-cyanoacetate
- 8 1-Guanyl-3,5-dimethyl-pyrazole Nitrate
- VIII Appendix
- 1 Conversion of Dicyclohexylammonium Salts of Protected Amino Acids to the Free Acids
- 2 Preparation pf Analytical Samples.