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03532nam a22003255i 4500 |
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978-3-7091-6308-5 |
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20191027191830.0 |
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cr nn 008mamaa |
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121227s2000 au | s |||| 0|eng d |
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|a 9783709163085
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|a 10.1007/978-3-7091-6308-5
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Prion Diseases
|b Diagnosis and Pathogenesis /
|c edited by Martin H. Groschup, Hans Kretzschmar.
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| 250 |
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|a 1st ed. 2000.
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| 260 |
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|a Vienna :
|b Springer Vienna :
|b Imprint: Springer,
|c 2000.
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| 300 |
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|a IX, 294 p.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Archives of Virology. Supplementa,
|v 16
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| 505 |
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|a Pathogenesis of Prion Diseases -- Prions: from neurografts to neuroinvasion -- Follicular dendritic cells in scrapie pathogenesis -- Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep -- Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice -- Pathogenesis of natural scrapie in sheep -- Animal Models for Priorn Diseases -- Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrPC -- Analyzing the influence of PrP primary structure on prion pathogenesis in transgenic mice -- A single amino acid alteration in murine PrP dramatically alters TSE incubation time -- A transgenic model of a familial prion disease -- Transgenic models of prion disease -- Epidemiology and Diagnosis of Prion Diseases -- Surveillance of BSE -- Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs) -- Pathology of variant Creutzfeldt-Jakob disease -- Clinical and differential diagnosis of Creutzfeldt-Jakob disease -- Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases -- Detection of PrPSc in subclinical BSE with the paraffin-embedded tissue (PET) blot -- Sheep and goats: natural and experimental TSEs and factors influencing incidence of disease -- Application of Prionics Western blotting procedure to screen for BSE in cattle regularly slaughtered at Swiss abattoirs -- Specific determination of the proteinase K-resistant form of the prion protein using two-site immunometric assays. Application to the post-mortem diagnosis of BSE -- Characterization of the Infectious Agent -- PrPSc typing by N-terminal sequencing and mass spectrometry -- Characterization of BSE and scrapie strains/isolates -- Quantitative traits of prion strains are enciphered in the conformation of the prion protein -- Structure and Function of PrP -- Function of PrPc as a copper-binding protein at the synapse -- The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations -- Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro -- PrP Conversion -- Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs -- The use of monoclonal antibody epitopes for tagging PrP in conversion experiments -- Listed in Current Contents.
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| 650 |
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|a Virology.
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| 650 |
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|a Pathology.
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| 650 |
1 |
4 |
|a Virology.
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| 650 |
2 |
4 |
|a Pathology.
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| 700 |
1 |
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|a Groschup, Martin H.
|e editor.
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| 700 |
1 |
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|a Kretzschmar, Hans.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-3-7091-6308-5
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