Combined Effects of Drugs and Toxic Agents Modern Evaluation in Theory and Practice /
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| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
Vienna :
Springer Vienna : Imprint: Springer,
1993.
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| Edition: | 1st ed. 1993. |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-7091-9276-4 |
Table of Contents:
- 1 Principle considerations of drug actions and interactions
- 1.1 Introduction
- 1.2 Dose-response curves
- 1.3 Time course of effects
- 1.4 Phenomena and mechanisms: interactions between drugs - antagonism and synergism
- 2 Concepts and models of interactions - additivity and independence
- 2.1 Concept and phenomenon of additivity
- 2.2 Site-directed analysis
- 2.3 Concept of independence
- 2.4 Relationship between additivity and independence
- 2.5 Summary and conclusions
- 2.6 Tips and hints
- 3 Synergism/potentiation and antagonism - phenomena and mechanisms
- 3.1 The current dilemma
- 3.2 Towards a uniform characterization of synergism/potentiation and antagonism
- 3.3 Potentiation (synergism)
- 3.4 Antagonism
- 3.5 Comparison of complex with simple interactions
- 3.6 Quantitative expression of combined effects
- 3.7 Suggestions for quantitation of combined effects
- 3.8 Tips and hints
- 4 Evaluation by dose-response curves
- 4.1 New methodological approach: fixed-dose studies
- 4.2 Fixed dose-ratio combinations
- 4.3 Tips and hints
- 5 Evaluation by time-course studies
- 5.1 Time course of independent actions
- 5.2 Dose-additive time course
- 5.3 Statistical comparison of observed and expected time course
- 5.4 Time-course studies with log response scale
- 5.5 Comparison of time-course studies and dose-response studies
- 5.6 Conclusions
- 6 Single-dose and other studies
- 6.1 Single-dose studies
- 6.2 Other studies
- 7 Combined-effect graph and other graphs
- 7.1 The construction of the combined-effect graph
- 7.2 Comparison of observed with independent effects
- 7.3 Yonetani-Theorell plot for enzyme inhibitors
- 7.4 Tips and hints
- 8 Applications of the new approach and observations
- 8.1 Biochemistry and physiology/pathophysiology
- 8.2 Experimental pharmacology
- 8.3 Clinical pharmacology - drug combinations
- 8.4 Chemotherapy of infections and tumors
- 8.5 Experimental and environmental toxicology
- 8.6 Epidemiology - risks
- 8.7 Herbicides
- 8.8 Conclusions and discussion
- 9 A new and critical view of isobolograms
- 9.1 Inappropriate conclusions
- 9.2 Pitfalls
- 10 Comparison of the new with the conventional approach
- 10.1 Experimental dose-response curves and isobolograms
- 10.2 Evaluation of combined effects in the future
- Epilog
- Appendix A - Glossary of terms and abbreviations
- Appendix B - Guide to practical work: exercise examples
- References.