The Immune Synapse as a Novel Target for Therapy

Detalles Bibliográficos
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Graca, Luis. (Editor )
Formato: eBook
Lenguaje:English
Publicado: Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2008.
Edición:1st ed. 2008.
Colección:Progress in Inflammation Research,
Materias:
Acceso en línea:https://doi.org/10.1007/978-3-7643-8296-4
Tabla de Contenidos:
  • The immune synapse and T cell activation: regulation by chemokines
  • The induction of regulatory T cells by targeting the immune synapse
  • Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
  • Targeting CD4 for the induction of dominant tolerance
  • Anti-CD3: from T cell depletion to tolerance induction
  • Immune modulation by CD40L blockade
  • CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
  • Adhesion molecules as therapeutic targets
  • E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
  • FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
  • Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance
  • From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.