PEGylated Protein Drugs: Basic Science and Clinical Applications
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| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Basel :
Birkhäuser Basel : Imprint: Birkhäuser,
2009.
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| Edición: | 1st ed. 2009. |
| Colección: | Milestones in Drug Therapy,
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| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-3-7643-8679-5 |
Tabla de Contenidos:
- Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century
- Protein PEGylation, basic science and biological applications
- Reactive PEGs for protein conjugation
- Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation
- Enzymatic techniques for PEGylation of biopharmaceuticals
- The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites
- Protein conjugates purification and characterization
- PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals
- The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol)
- Pegfilgrastim — designing an improved form of rmetHuG-CSF
- PEGylation of human growth hormone: strategies and properties
- PEGylated ? interferons: two different strategies to achieve increased efficacy
- Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout
- Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent
- PEG: a useful technology in anticancer therapy
- Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines.