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| LEADER |
03985nam a22004215i 4500 |
| 001 |
978-4-431-27879-5 |
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20191028141955.0 |
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cr nn 008mamaa |
| 008 |
100301s2005 ja | s |||| 0|eng d |
| 020 |
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|a 9784431278795
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| 024 |
7 |
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|a 10.1007/4-431-27879-6
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Non-viral Gene Therapy
|b Gene Design and Delivery /
|c edited by Kazunari Taira, Kazunori Kataoka, Takuro Niidome.
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| 250 |
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|a 1st ed. 2005.
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| 260 |
# |
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|a Tokyo :
|b Springer Japan :
|b Imprint: Springer,
|c 2005.
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| 300 |
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|a XII, 487 p.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
0 |
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|a Molecules for Gene Therapy -- Recent Progress in Non-viral Gene Delivery -- Physical Chemistry of DNA-Carrier Complexes -- Liposomes -- Polymeric Gene Carriers -- Development of a Supramolecular Nanocarrier for Gene Delivery Based on Cationic Block Copolymers -- Chitosan -- Dendrimers as DNA Carriers -- Use of Synthetic Peptides for Non-viral Gene Delivery -- An Oligonucleotide Carrier Based on ?-1,3-Glucans -- Biological and Chemical Hybrid Vectors -- Controlled Gene Delivery -- Pharmacokinetics of Gene Delivery in Cells -- Active DNA Release from Complexes -- Controlled Release of DNA Using Thermoresponsive Polymers -- Active Transport of Exogenous Genes into the Nucleus -- Controlled Intracellular Localization of Oligonucleotides by Chemical Conjugation -- Functional Nucleotide Sequences Capable of Promoting Non-viral Genetic Transfer -- Shielding of Cationic Charge of the DNA Complex to Avoid Nonspecific Interactions for In Vivo Gene Delivery -- In Vivo Gene Transfer by Ligand-Modified Gene Carriers -- Optimizing Polyplexes into Synthetic Viruses for Tumor-Targeted Gene Therapy -- Gene Transfer and Target Diseases -- Clinical Trials Using Non-viral Gene Delivery Systems -- Current Protocols of Gene Delivery -- Evaluation of Size and Zeta Potential of DNA/Carrier Complexes -- Observation of DNA/Carrier Complexes Under Fluorescence Microscopy -- Synthesis of Chemically Modified Chitosan and a Study of Its Gene Transfection Efficiency -- Newly Designed DNA Fragments for Gene Correction -- Evaluation of Gene Expression In Vivo After Intravenous and Intraportal Administration of Lipoplexes -- Evaluation by Southern Blot Hybridization of DNA Administered with a Gene Carrier to Organs -- Evaluation of the Immune Response After Administration of Plasmid DNA-Non-viral Vector Complexes -- Gateway RNAi -- Design of Genes Based on Current RNA Technology -- Design of Intracellularly Active Ribozymes and siRNAs -- RNAi-Based Inhibition Specific for Mutant Alleles in Autosomal Dominant Diseases: Sequence-Dependent and -Independent Discrimination of Mutant and Wild-Type Alleles by siRNA -- In Vivo RNA Interference: Another Tool in the Box? -- Suppression of Gene Expression via Chromatin Remodeling and the siRNA-Induced Silencing of Transcription -- Intracellular Delivery of Nucleic Acids: Differences Between Transfection and siFection Reflect Differences Between DNA and RNA, and Between Oligodeoxynucleotides and Oligonucleotides -- In Vivo Antitumor Activity of a New Cationic Liposome siRNA Complex -- Enhancing RNAi with Synthetic RNA Duplexes.
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| 650 |
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0 |
|a Cell biology.
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| 650 |
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0 |
|a Biotechnology.
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| 650 |
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0 |
|a Molecular biology.
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| 650 |
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|a Genetic engineering.
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| 650 |
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0 |
|a Biochemical engineering.
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| 650 |
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|a Medical biochemistry.
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| 650 |
1 |
4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Biotechnology.
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| 650 |
2 |
4 |
|a Molecular Medicine.
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| 650 |
2 |
4 |
|a Genetic Engineering.
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| 650 |
2 |
4 |
|a Biochemical Engineering.
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| 650 |
2 |
4 |
|a Medical Biochemistry.
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| 700 |
1 |
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|a Taira, Kazunari.
|e editor.
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| 700 |
1 |
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|a Kataoka, Kazunori.
|e editor.
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| 700 |
1 |
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|a Niidome, Takuro.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/4-431-27879-6
|