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03695nam a22002895i 4500 |
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978-94-010-9127-5 |
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20190619231247.0 |
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cr nn 008mamaa |
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121227s1998 ne | s |||| 0|eng d |
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|a 9789401091275
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| 024 |
7 |
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|a 10.1007/978-94-010-9127-5
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 100 |
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|a Franklin, T.
|e author.
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| 245 |
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|a Biochemistry and Molecular Biology of Antimicrobial Drug Action
|c by T. Franklin.
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| 250 |
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|a 1st ed. 1998.
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| 260 |
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|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 1998.
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| 300 |
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|a X, 166 p. 18 illus.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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|a 1 The Development of Antimicrobial Agents Past, Present and Future -- 1.1 The social and economic importance of antimicrobial agents -- 1.2 An outline of the historical development of antimicrobial agents -- 1.3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds -- 1.4 Uncovering the molecular basis of antimicrobial action -- 1.5 Scope and layout of the present book -- 2 Vulnerable Shields — The Cell Walls of Bacteria and Fungi -- 2.1 Functions of the cell wall -- 2.2 Structure of the bacterial wall -- 2.3 Structure and biosynthesis of peptidoglycan -- 2.4 Antibiotics that inhibit peptidoglycan biosynthesis -- 2.5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria -- 2.6 The structure of the fungal cell wall -- 2.7 Inhibitors of the biosynthesis of the fungal cell wall -- 3 Antiseptics, Antibiotics and the Cell Membrane -- 3.1 Microbe killers: antiseptics and disinfectants -- 3.2 Polypeptide antibiotics -- 3.3 lonophoric antibiotics -- 3.4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols -- 4 Inhibitors of Nucleic Acid Synthesis -- 4.1 Compounds affecting the biosynthesis and utilization of nucleotide precursors -- 4.2 Inhibitors of nucleic acid biosynthesis at the polymerization stage -- 5 Inhibitors of Protein Biosynthesis -- 5.1 Ribosomes -- 5.2 Stages in protein biosynthesis -- 5.3 Puromycin -- 5.4 Inhibitors of aminoacyl-tRNA formation -- 5.5 Inhibitors of initiation and translation -- 5.6 Inhibitors of peptide bond formation and translocation -- 5.7 Nitrofurantoin — a ribosomal poison? -- 5.8 Effects of inhibitors of 70S ribosomes on eukaryotic cells -- 6 Antimicrobial Drugs with other Modes of Action -- 6.1 Antibacterial agents -- 6.2 A unique antifungal antibiotic — griseofulvin -- 6.3 Antiviral agents -- 6.4 Antiprotozoal agents -- 7 Penetrating the Defences: How Antimicrobial Drugs Reach Their Targets -- 7.1 Cellular permeability barriers to drug penetration -- 7.2 Multidrug efflux in bacteria -- 7.3 Examples of the uptake of antibacterial drugs -- 7.4 Uptake of antimicrobial drugs by eukaryotic pathogens -- 8 The Genetic Basis of Resistance to Antimicrobial Drugs -- 8.1 Mutations and the origins of drug-resistance genes -- 8.2 Gene mobility and transfer in bacterial drug resistance -- 8.3 Global regulators of drug resistance in Gram-negative bacteria -- 9 Biochemical Mechanisms of Resistance to Antimicrobial Drugs -- 9.1 Enzymic inactivation of drugs -- 9.2 Modification of drug targets -- 9.3 Drug efflux pumps -- 9.4 Other mechanisms of resistance -- 9.5 Drug resistance and the future of chemotherapy.
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| 650 |
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|a Biochemistry.
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| 650 |
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|a Biochemistry, general.
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| 650 |
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|a Science, Humanities and Social Sciences, multidisciplinary.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-94-010-9127-5
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