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160509s2016 gw | s |||| 0|eng d |
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|a 9783319262390
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| 024 |
7 |
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|a 10.1007/978-3-319-26239-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Cellular Ageing and Replicative Senescence /
|c edited by Suresh I.S. Rattan, Leonard Hayflick.
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| 250 |
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|a 1st ed. 2016.
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| 260 |
# |
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|a Cham :
|b Springer International Publishing :
|b Imprint: Springer,
|c 2016.
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| 300 |
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|a VIII, 364 p. 27 illus., 18 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Healthy Ageing and Longevity,
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| 505 |
0 |
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|a Preface -- Section I History and origins -- Origins of the Hayflick system, the phenomenon and the limit -- Early testing and development of the Hayflick system -- Section II Serial passaging and progressive changes -- Slowing down of the cell cycle -- Ageing of cells in the centenarians and long-lived -- Aging of the stem cells -- Aging and senescence in the immune cells in vitro and in vivo -- Accelerated cellular aging in progeroid syndromes -- Telomere and genomic instability -- Mechanistic explanation for cellular aging in vitro: the commitment theory -- Modelling cellular aging senescence -- Section-III Regulation, and senescence -- Cell cycle checkpoints and regulators of senescence -- Oxidative stress and cellular ageing -- Biomarkers of replicative senescence revisited -- Cellular aging and tumour regulation -- Declining Protein turnover and degradation -- Section IV Modulating the system -- Stress induced premature senescence (SIPS) -- Mild stress-induced hormesis -- Food, hormones and growth factors in cellular aging -- sncRNAs in cellular aging and senescence -- Elimination of senescent cells for rejuvenation -- Section-V RECAPITULATION -- The past, present and the future of cellular aging and replicative senescence -- Index.
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| 650 |
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0 |
|a Cytogenetics.
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| 650 |
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0 |
|a Cell biology.
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| 650 |
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|a Geriatrics.
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| 650 |
1 |
4 |
|a Cytogenetics.
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| 650 |
2 |
4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Geriatrics/Gerontology.
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| 700 |
1 |
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|a Rattan, Suresh I.S.
|e editor.
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| 700 |
1 |
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|a Hayflick, Leonard.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
|