Cellular Ageing and Replicative Senescence /
| Autor Corporativo: | |
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| Otros Autores: | , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Cham :
Springer International Publishing : Imprint: Springer,
2016.
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| Edición: | 1st ed. 2016. |
| Colección: | Healthy Ageing and Longevity,
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| Materias: |
Tabla de Contenidos:
- Preface
- Section I History and origins
- Origins of the Hayflick system, the phenomenon and the limit
- Early testing and development of the Hayflick system
- Section II Serial passaging and progressive changes
- Slowing down of the cell cycle
- Ageing of cells in the centenarians and long-lived
- Aging of the stem cells
- Aging and senescence in the immune cells in vitro and in vivo
- Accelerated cellular aging in progeroid syndromes
- Telomere and genomic instability
- Mechanistic explanation for cellular aging in vitro: the commitment theory
- Modelling cellular aging senescence
- Section-III Regulation, and senescence
- Cell cycle checkpoints and regulators of senescence
- Oxidative stress and cellular ageing
- Biomarkers of replicative senescence revisited
- Cellular aging and tumour regulation
- Declining Protein turnover and degradation
- Section IV Modulating the system
- Stress induced premature senescence (SIPS)
- Mild stress-induced hormesis
- Food, hormones and growth factors in cellular aging
- sncRNAs in cellular aging and senescence
- Elimination of senescent cells for rejuvenation
- Section-V RECAPITULATION
- The past, present and the future of cellular aging and replicative senescence
- Index.