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03144nam a22003135i 4500 |
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190423s2019 xxu| s |||| 0|eng d |
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|a 9781493994205
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|a 10.1007/978-1-4939-9420-5
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Experimental Cholestasis Research /
|c edited by Mathieu Vinken.
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| 250 |
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|a 1st ed. 2019.
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| 260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2019.
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| 300 |
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|a XIII, 399 p. 74 illus., 60 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 1981
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| 505 |
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|a Mechanisms of Drug-Induced Cholestasis -- LC-MS/MS Analysis of Bile Acids in In Vitro Samples -- Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis -- Vesicle-Based and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function -- The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity -- In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids -- Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy -- The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis -- Measuring Apoptosis and Necrosis in Cholestatic Liver Injury -- Necrosome Formation and Necroptosis in Experimental Cholestasis -- Proteomics in Primary Biliary Cholangitis -- Transcriptomics Analysis of Cholestatic Compounds In Vitro -- Systems Microscopy of Stress Response Pathways in Cholestasis Research -- Mouse Models for Diseases in the Cholangiocyte Lineage -- Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis -- 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research -- A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis -- Zebrafish as a Model to Study Cholestatic Liver Diseases -- Set-Up and Use of HepaRG Cells in Cholestasis Research -- Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis -- Establishment of Sandwich Cultures of Primary Human Hepatocytes -- Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes -- Ex Vivo Model in Cholestasis Research -- Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies -- Use of Biliary Organoids in Cholestasis Research -- In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis.
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| 650 |
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|a Pharmacology.
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| 650 |
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|a Hepatology.
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| 650 |
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|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Hepatology.
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| 700 |
1 |
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|a Vinken, Mathieu.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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