Current Trends in Monoclonal Antibody Development and Manufacturing /

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Shire, Steven J. (Editor), Gombotz, Wayne. (Editor), Bechtold-Peters, Karoline. (Editor), Andya, James. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2010.
Edition:1st ed. 2010.
Series:Biotechnology: Pharmaceutical Aspects ; XI
Subjects:
Table of Contents:
  • Design Of Therapeutic MABS
  • CDR Repair: A Novel Approach to Antibody Humanization
  • Nanobodies, Single-Domain Antigen-Binding Fragments of Camelid Heavy-Chain Antibodies
  • Expression and Production of MABS
  • GPEx® A Flexible Method for the Rapid Generation of Stable, High Expressing, Antibody Producing Mammalian Cell Lines
  • Advancing Our Cell Culture Platform: Incorporating Lessons Learned and New Technologies
  • Recovery and Purification
  • Addressing Changes Associated with Technology Transfer: A Case Study
  • Concepts for Disposables in Biopharmaceutical Manufacture
  • Formulation and Delivery
  • Formulation and Delivery Issues for Monoclonal Antibody Therapeutics
  • Challenges in the Development of High Protein Concentration Formulations
  • Protein Immobilization by Crystallization and Precipitation: An Alternative to Lyophilization
  • Analytics and Specification Setting for MABS
  • Characterizing High Affinity Antigen/Antibody Complexes by Kinetic and Equilibrium Based Methods
  • Analytical Characterization of Monoclonal Antibodies: Linking Structure to Function
  • Analysis of Irreversible Aggregation, Reversible Self-association and Fragmentation of Monoclonal Antibodies by Analytical Ultracentrifugation
  • Biophysical Signatures of Monoclonal Antibodies
  • Pharmacokinetics and Immunogenicity
  • Impact of Fc Glycosylation on Monoclonal Antibody Effector Functions and Degradation by Proteases
  • Immunogenicity Assessment of Antibody Therapeutics
  • Armed Antibodies and New Classes of Antibodies
  • Production of Monoclonal Antibodies in E. coli
  • Recent Advancements in the Use of Antibody Drug Conjugates for Cancer Therapy
  • Antibody Radiolabeling.