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03798nam a22003375i 4500 |
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20210506155344.0 |
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100301s2010 xxu| s |||| 0|eng d |
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|a 9781441908407
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| 024 |
7 |
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|a 10.1007/978-1-4419-0840-7
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Enzyme- and Transporter-Based Drug-Drug Interactions :
|b Progress and Future Challenges /
|c edited by K. Sandy Pang, A. David Rodrigues, Raimund M. Peter.
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| 250 |
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|a 1st ed. 2010.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2010.
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| 300 |
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|a XVIII, 746 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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|a Determinants of Drug ADME -- Enzymatic Basis of Phase I and Phase II Drug Metabolism -- Transporters: Importance in Drug Absorption, Distribution, and Removal -- ADME Pharmacogenetics and Its Impact on Drug–Drug Interactions -- Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters -- Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Body Clearances -- Methods For The Study Of Drug-Drug Interactions -- In Silico Approaches to Predict DDIs -- In Vitro Techniques to Study Drug–Drug Interactions of Drug Metabolism: Cytochrome P450 -- The In Vitro Characterization of Inhibitory Drug–Drug Interactions Involving UDP-Glucuronosyltransferase -- In Vitro Techniques to Study Transporter-Based DDI -- In Vitro Techniques to Study Drug–Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters -- Use of In Vivo Animal Models to Assess Drug–Drug Interactions -- Extrapolation of In Vitro Metabolic and P-Glycoprotein-Mediated Transport Data to In Vivo by Modeling and Simulations -- Translation of In Vitro Metabolic Data to Predict In Vivo Drug–Drug Interactions: IVIVE and Modeling and Simulations -- Absorption Models to Examine Bioavailability and Drug–Drug Interactions in Humans -- Management of Drug Interactions of New Drugs in Multicenter Trials Using the Metabolism and Transport Drug Interaction Database© -- Web-Based Database as a Tool to Examine Drug–Drug Interactions Involving Transporters -- Impact Of Drug-Drug Interactions -- Drug Disposition and Drug–Drug Interactions: Importance of First-Pass Metabolism in Gut and Liver -- Transporter-Based Drug–Drug Interactions and Their Effect on Distribution Volumes -- Inactivation of Human Cytochrome P450 Enzymes and Drug–Drug Interactions -- Allosteric Enzyme- and Transporter-Based Interactions -- The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans -- Herbal Supplement-Based Interactions -- Anticipating and Minimizing Drug Interactions in a Drug Discovery and Development Setting: An Industrial Perspective -- Clinical Studies of Drug–Drug Interactions: Design and Interpretation -- Toxicological Consequences of Drug–Drug Interactions -- Regulatory Aspects And Future Developments Involving DDI -- Complex Drug Interactions: Significance and Evaluation -- Drug–Drug Interactions: Communicating Post-market Drug Safety Information in the USA -- Drug–Drug Interactions: What Have We Learned and Where Are We Going?.
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| 650 |
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|a Pharmacology.
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| 650 |
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0 |
|a Analytical chemistry.
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| 650 |
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|a Medicinal chemistry.
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| 650 |
1 |
4 |
|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Analytical Chemistry.
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| 650 |
2 |
4 |
|a Medicinal Chemistry.
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| 700 |
1 |
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|a Pang, K. Sandy.
|e editor.
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| 700 |
1 |
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|a Rodrigues, A. David.
|e editor.
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| 700 |
1 |
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|a Peter, Raimund M.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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