Enzyme- and Transporter-Based Drug-Drug Interactions : Progress and Future Challenges /
| Autor Corporativo: | |
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| Otros Autores: | , , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
2010.
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| Edición: | 1st ed. 2010. |
| Materias: |
Tabla de Contenidos:
- Determinants of Drug ADME
- Enzymatic Basis of Phase I and Phase II Drug Metabolism
- Transporters: Importance in Drug Absorption, Distribution, and Removal
- ADME Pharmacogenetics and Its Impact on Drug–Drug Interactions
- Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters
- Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Body Clearances
- Methods For The Study Of Drug-Drug Interactions
- In Silico Approaches to Predict DDIs
- In Vitro Techniques to Study Drug–Drug Interactions of Drug Metabolism: Cytochrome P450
- The In Vitro Characterization of Inhibitory Drug–Drug Interactions Involving UDP-Glucuronosyltransferase
- In Vitro Techniques to Study Transporter-Based DDI
- In Vitro Techniques to Study Drug–Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters
- Use of In Vivo Animal Models to Assess Drug–Drug Interactions
- Extrapolation of In Vitro Metabolic and P-Glycoprotein-Mediated Transport Data to In Vivo by Modeling and Simulations
- Translation of In Vitro Metabolic Data to Predict In Vivo Drug–Drug Interactions: IVIVE and Modeling and Simulations
- Absorption Models to Examine Bioavailability and Drug–Drug Interactions in Humans
- Management of Drug Interactions of New Drugs in Multicenter Trials Using the Metabolism and Transport Drug Interaction Database©
- Web-Based Database as a Tool to Examine Drug–Drug Interactions Involving Transporters
- Impact Of Drug-Drug Interactions
- Drug Disposition and Drug–Drug Interactions: Importance of First-Pass Metabolism in Gut and Liver
- Transporter-Based Drug–Drug Interactions and Their Effect on Distribution Volumes
- Inactivation of Human Cytochrome P450 Enzymes and Drug–Drug Interactions
- Allosteric Enzyme- and Transporter-Based Interactions
- The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans
- Herbal Supplement-Based Interactions
- Anticipating and Minimizing Drug Interactions in a Drug Discovery and Development Setting: An Industrial Perspective
- Clinical Studies of Drug–Drug Interactions: Design and Interpretation
- Toxicological Consequences of Drug–Drug Interactions
- Regulatory Aspects And Future Developments Involving DDI
- Complex Drug Interactions: Significance and Evaluation
- Drug–Drug Interactions: Communicating Post-market Drug Safety Information in the USA
- Drug–Drug Interactions: What Have We Learned and Where Are We Going?.