Mast Cells and Tumours : from Biology to Clinic /
| Autores principales: | , |
|---|---|
| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2011.
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| Edición: | 1st ed. 2011. |
| Materias: |
Tabla de Contenidos:
- Introduction
- 1. The mast cell
- 1.1. A historical overview
- 1.2. Biology of mast cells
- 2. Mast cell mediators
- 2.1. Granule composition
- 2.2. Histamine and serotonin
- 2.3. Proteases
- 2.4. Lipid mediators
- 2.5. Cytokines and growth factors
- 2.6. Chemokines
- 3. The tumour cell
- 3.1. Biology of tumour cell
- 3.2. The importance of microenvironment in tumor metastasis
- 3.3. The “seed and soil” theory
- 4. Tumour angiogenesis
- 4.1. The angiogenic switch
- 4.2. Phenotypic and genotypic characteristics of tumor vessels and genetic evidence that tumours are angiogenesis-dependent
- 4.3. What is the evidence that genetic instability promotes the angiogenic switch?
- 4.4. Hypoxic regulation of tumour angiogenesis
- 4.5. The role of pericytes in tumour angiogenesis
- 4.6. The role of inflammatory cells in tumour angiogenesis
- 4.7. Participation of hematopoietic cells and endothelial precursor cells to tumour angiogenesis
- 4.8. Alternative mechanisms of tumour angiogenesis
- 4.9. Vascular cooption
- 4.10. The prognostic significance of tumour angiogenesis
- 4.11. Angiogenesis is not necessarily involved in tumour progression
- 5. Mast cells and tumours
- 5.1. Mast cells and tumour growth in humans: pro and contra
- 6. Mast cells and tumour angiogenesis
- 6.1. Mast cell-induced angiogenesis studied by means of in vitro and in vivo assays
- 6.2. Mast cell-induced angiogenesis studied by means of experimental carcinogenesis
- 6.3. Angiogenic factors stored in mast cells
- 6.4. Mast cells and angiogenesis in human solid tumours
- 6.5. Mast cells and angiogenesis in human hematological tumours
- 7. Mast cells and tumour lymphangiogenesis
- 8. Drug affecting mast cells
- Concluding remarks and perspectives
- References. .