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100301s2006 xxu| s |||| 0|eng d |
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|a 9781597452175
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| 024 |
7 |
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|a 10.1385/1597452173
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a High Content Screening /
|c edited by D. Lansing Taylor.
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| 250 |
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|a 1st ed. 2006.
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| 260 |
# |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2006.
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| 300 |
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|a 464 p. 168 illus. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 356
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| 505 |
0 |
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|a to High Content Screening -- Past, Present, and Future of High Content Screening and the Field of Cellomics -- A Pharmaceutical Company User’s Perspective on the Potential of High Content Screening in Drug Discovery -- Linking Microscopy and High Content Screening in Large-Scale Biomedical Research -- Instrumentation, Biological Application Software, and Sample Preparation -- Requirements, Features, and Performance of High Content Screening Platforms -- Characteristics and Value of Directed Algorithms in High Content Screening -- Characteristics and Value of Machine Learning for Imaging in High Content Screening -- Tools for Quantitative and Validated Measurements of Cells -- Automated Cell Plating and Sample Treatments for Fixed Cells in High Content Assays -- Differentiating Primary Human Cells in Rapid-Throughput Discovery Applications -- Use of the CellCard™ System for Analyzing Multiple Cell Types in Parallel -- Reagents -- Reagents to Measure and Manipulate Cell Functions -- Fluorescent Proteins and Engineered Cell Lines -- Optimizing the Integration of Immunoreagents and Fluorescent Probes for Multiplexed High Content Screening Assays -- The HaloTag™ -- Protein Labeling With FlAsH and ReAsH -- Exploiting Network Biology to Improve Drug Discovery -- Physiological Indicators of Cell Function -- The Use of siRNA to Validate Immunofluorescence Studies -- Caged Substrates Applied to High Content Screening -- Informatics and Bioinformatics -- Overview of Informatics for High Content Screening -- Large-Scale Data Management for High Content Screening -- An Integrated Biomedical Knowledge Extraction and Analysis Platform -- Visualization of High Content Screening Data -- Pathway Mapping Tools for Analysis of High Content Data -- Assays and Applications of High Content Screening -- Systems Biology in Cancer Research -- Target Validation in Drug Discovery -- High Content Screening as a Screening Tool in Drug Discovery -- Discovery of Protein Kinase Phosphatase Inhibitors -- High Content Translocation Assays for Pathway Profiling -- In Vitro Cytotoxicity Assessment -- Neurite Outgrowth in Retinal Ganglion Cell Culture.
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| 650 |
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|a Cell biology.
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| 650 |
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|a Medicinal chemistry.
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| 650 |
1 |
4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Medicinal Chemistry.
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| 700 |
1 |
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|a Taylor, D. Lansing.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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