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181019s2019 xxu| s |||| 0|eng d |
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|a 9781493988204
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| 024 |
7 |
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|a 10.1007/978-1-4939-8820-4
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Protein Misfolding Diseases :
|b Methods and Protocols /
|c edited by Cláudio M. Gomes.
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| 250 |
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|a 1st ed. 2019.
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| 260 |
# |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2019.
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| 300 |
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|a XIII, 338 p. 77 illus., 58 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 1873
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| 505 |
0 |
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|a Biophysical and Spectroscopic Methods for Monitoring Protein Misfolding and Amyloid Aggregation -- Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates -- Vesicle-Based Assays to Study Membrane Interactions of Amyloid Peptides -- Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis -- A Multipronged Method for Unveiling Subtle Structural-Functional Defects of Mutant Chaperone Molecules Causing Human Chaperonopathies -- High-Throughput Microplate-Based Fluorescence Assays for Studying Stochastic Aggregation of Superoxide Dismutase-1 -- Methods for Structural Analysis of Amyloid Fibrils in Misfolding Diseases -- Assays for Light Chain Amyloidosis Formation and Cytotoxicity -- Monitoring Aggregate Clearance and Formation in Cell-Based Assays -- Monitoring Proteome Stress in Live Cells Using HaloTag-Based Fluorogenic Sensor -- Quantification of Protein Aggregates Using Bimolecular Fluorescence Complementation -- Screening Protein Aggregation in Cells Using Fluorescent Labels Coupled to Flow Cytometry -- Induction of Cu/Zn Superoxide Dismutase (SOD1) Aggregation in Living Cells -- A Cell Model for HSP60 Deficiencies: Modeling Different Levels of Chaperonopathies Leading to Oxidative Stress and Mitochondrial Dysfunction -- Super-Resolution Fluorescence Imaging of Mutant Huntingtin Aggregation in Cells -- Thermal Shift and Stability Assays of Disease-Related Misfolded Proteins Using Differential Scanning Fluorimetry -- Methods to Screen Compounds against Mutant p53 Misfolding and Aggregation for Cancer Therapeutics -- Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases -- Constructing Kinetically Controlled Denaturation Isotherms of Folded Proteins Using Denaturant-Pulse Chaperonin Binding -- In Vitro Prion Amplification Methodology for Inhibitor Screening -- SolubiS: Optimizing Protein Solubility by Minimal Point Mutations.
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| 650 |
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|a Proteins .
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| 650 |
1 |
4 |
|a Protein Science.
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| 700 |
1 |
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|a Gomes, Cláudio M.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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