New Approaches to Drug Discovery /
| Corporate Author: | |
|---|---|
| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2016.
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| Edition: | 1st ed. 2016. |
| Series: | Handbook of Experimental Pharmacology,
232 |
| Subjects: |
Table of Contents:
- Preface
- Part 1. Historical View
- Drug discovery in the past and today.Part 2. Target Discovery
- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis
- Part 3. Lead generation and Optimization
- Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals
- Part 4. Test systems for Efficacy and Safety
- In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.