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180628s2018 xxu| s |||| 0|eng d |
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|a 9781493985593
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024 |
7 |
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|a 10.1007/978-1-4939-8559-3
|2 doi
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040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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245 |
1 |
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|a Progranulin :
|b Methods and Protocols /
|c edited by Andrew Bateman, Hugh P.J. Bennett, Siu Tim Cheung.
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250 |
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|a 1st ed. 2018.
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260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2018.
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300 |
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|a XIII, 363 p. 79 illus., 56 illus. in color. :
|b online resource.
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336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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490 |
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|a Methods in Molecular Biology,
|v 1806
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|a A Brief Overview of Progranulin in Health and Disease -- Chromatographic Methods for the Purification of Granulin Peptides -- Methods for Expression and Purification of Biologically Active Recombinant Progranulin -- Large-Scale Generation of Recombinant Granulin Peptides in E. coli -- Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine Bridging -- Data Mining: Applying the AD&FTD Mutation Database to Progranulin -- Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human Diseases -- Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic Biomarker -- Analysis of Progranulin-Mediated Akt and MAPK Activation -- Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer Models -- Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell Features -- Methods to Study the Role of Progranulin in the Tumor Microenvironment -- Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegans -- The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response -- Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function -- Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice -- Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the Brain -- The Interaction between Progranulin with Sortilin and the Lysosome -- Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo Development -- Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory Arthritis -- Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro Studies -- Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models.
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650 |
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|a Proteins .
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650 |
1 |
4 |
|a Protein Science.
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700 |
1 |
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|a Bateman, Andrew.
|e editor.
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700 |
1 |
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|a Bennett, Hugh P.J.
|e editor.
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700 |
1 |
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|a Cheung, Siu Tim.
|e editor.
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710 |
2 |
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|a SpringerLink (Online service)
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773 |
0 |
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|t Springer eBooks
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900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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