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02605nam a22003015i 4500 |
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20201015102903.0 |
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cr nn 008mamaa |
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181205s2019 xxu| s |||| 0|eng d |
| 020 |
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|a 9781493988914
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| 024 |
7 |
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|a 10.1007/978-1-4939-8891-4
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
0 |
|a Systems Chemical Biology :
|b Methods and Protocols /
|c edited by Slava Ziegler, Herbert Waldmann.
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| 250 |
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|a 1st ed. 2019.
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| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2019.
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| 300 |
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|a XI, 315 p. 65 illus., 43 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Molecular Biology,
|v 1888
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| 505 |
0 |
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|a 1. PREDECT protocols for complex 2D/3D cultures -- 2. Phenotypic Screening using Mouse and Human Stem Cell-based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses -- 3. Quantitative, Real-Time Measurements of Intracellular Target Engagement Using Energy Transfer -- 4. Target Engagement of Small Molecules – Thermal Profiling Approaches on Different Levels -- 5. Visualizing Bio-active Small Molecules by Alkyne-tagging and Slit-scanning Raman Microscopy -- 6. The Cell Painting Assay as a screening tool for the discovery of bioactivities in new chemical matter -- 7. Proteomic Profiling for Target Identification of Biologically Active Small Molecules using 2-D DIGE -- 8. Examining Cellular Responses to Kinase Drug Inhibition through Phosphoproteome Mapping of Substrates -- 9. CRISPR/Cas9-based Chemogenomic Profiling in Mammalian Cells -- 10. Exome Sequencing of Drug-resistant Clones for Target Identification -- 11. The use of large-scale chemically-induced transcriptome data acquired from LINCS to study small molecules -- 12. Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Co-addictions in Cancer -- 13. Predicting Drug Interactions from Chemogenomics using INDIGO -- 14. Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines -- 15. Web-based tools for Polypharmacology Prediction -- 16. In silico Target Prediction for Small Molecules.
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| 650 |
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0 |
|a Bioinformatics.
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| 650 |
1 |
4 |
|a Bioinformatics.
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| 700 |
1 |
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|a Ziegler, Slava.
|e editor.
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| 700 |
1 |
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|a Waldmann, Herbert.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
|
| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|