Systems Chemical Biology : Methods and Protocols /
| Autor Corporativo: | |
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| Otros Autores: | , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer New York : Imprint: Humana,
2019.
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| Edición: | 1st ed. 2019. |
| Colección: | Methods in Molecular Biology,
1888 |
| Materias: |
Tabla de Contenidos:
- 1. PREDECT protocols for complex 2D/3D cultures
- 2. Phenotypic Screening using Mouse and Human Stem Cell-based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses
- 3. Quantitative, Real-Time Measurements of Intracellular Target Engagement Using Energy Transfer
- 4. Target Engagement of Small Molecules – Thermal Profiling Approaches on Different Levels
- 5. Visualizing Bio-active Small Molecules by Alkyne-tagging and Slit-scanning Raman Microscopy
- 6. The Cell Painting Assay as a screening tool for the discovery of bioactivities in new chemical matter
- 7. Proteomic Profiling for Target Identification of Biologically Active Small Molecules using 2-D DIGE
- 8. Examining Cellular Responses to Kinase Drug Inhibition through Phosphoproteome Mapping of Substrates
- 9. CRISPR/Cas9-based Chemogenomic Profiling in Mammalian Cells
- 10. Exome Sequencing of Drug-resistant Clones for Target Identification
- 11. The use of large-scale chemically-induced transcriptome data acquired from LINCS to study small molecules
- 12. Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Co-addictions in Cancer
- 13. Predicting Drug Interactions from Chemogenomics using INDIGO
- 14. Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines
- 15. Web-based tools for Polypharmacology Prediction
- 16. In silico Target Prediction for Small Molecules.