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150802s2016 xxu| s |||| 0|eng d |
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|a 9781493926275
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|a 10.1007/978-1-4939-2627-5
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
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|a Systems Biology of Alzheimer's Disease /
|c edited by Juan I. Castrillo, Stephen G. Oliver.
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| 250 |
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|a 1st ed. 2016.
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| 260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2016.
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| 300 |
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|a XVI, 563 p. 74 illus., 56 illus. in color. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 1303
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| 505 |
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|a Alzheimer’s as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks -- Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer’s Disease -- The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer’s Disease -- Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing -- Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models -- Advanced Optical Super-Resolution Method and Techniques for the Study of β-Amyloid Aggregation In Vitro and In Vivo -- Protocols for Monitoring the Development of Tau Pathology in Alzheimer’s Disease -- LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells -- Advanced Mitochondrial Respiration Assay for Evaluation of Mitochondrial Dysfunction in Alzheimer’s Disease -- Analysis of Microglial Proliferation in Alzheimer’s Disease -- Yeast as a Model for Alzheimer’s Disease: Latest Studies and Advanced Strategies -- Yeast as a Model for Studies on Aβ Aggregation Toxicity in Alzheimer’s Disease, Autophagic Responses, and Drug Screening -- Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer’s Disease -- Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer’s Disease Phenotype in Mouse Models -- Gene Expression Studies on Human Trisomy 21 iPSCs and Neurons: Towards Mechanisms Underlyi ng Down’s Syndrome and Early Alzheimer’s Disease-Like Pathologies -- Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer’s Disease -- Next Generation Sequencing in Alzheimer’s Disease -- Pooled-DNA Sequencing for Elucidating New Genomic Risk Factors, Rare Variants Underlying Alzheimer’s Disease -- New Genome-Wide Methods for Elucidation of Candidate Copy Number Variations (CNVs) Contributing to Alzheimer’s Disease Heritability -- RNA-Sequencing to Elucidate Early Patterns of Dysregulation Underlying the Onset of Alzheimer’s Disease -- Systems Biology Approaches to the Study of Biological Networks Underlying Alzheimer’s Disease: Role of miRNAs -- The Emerging Role of Metalloproteomics in Alzheimer’s Disease Research -- Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation -- Advanced Shotgun Lipidomics for Characterization of Altered Lipid Patterns in Neurodegenerative Diseases and Brain Injury -- AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer’s Disease Pathogenesis -- A Computational Network Biology Approach to Uncover Novel Genes Related to Alzheimer’s Disease -- Network Approaches to the Understanding of Alzheimer’s Disease: From Model Organisms to Humans -- Characterization of Genetic Networks Associated with Alzheimer's Disease -- Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer’s Disease -- The SDREM Method for Reconstructing Signaling and Regulatory Response Networks: Applications for Studying Disease Progression -- Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease -- Plasma Proteomics Biomarkers in Alzheimer's Disease: Latest Advances and Challenges -- A Practical Guide For Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology.
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| 650 |
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|a Neurosciences.
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| 650 |
1 |
4 |
|a Neurosciences.
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| 700 |
1 |
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|a Castrillo, Juan I.
|e editor.
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| 700 |
1 |
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|a Oliver, Stephen G.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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