Spotlight on Familial and Hereditary Gastric Cancer /

Detalles Bibliográficos
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Corso, Giovanni. (Editor ), Roviello, Franco. (Editor )
Formato: eBook
Lenguaje:English
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Materias:
Tabla de Contenidos:
  • Foreword
  • Preface.-I General Issues
  • Historical overview of familial gastric cancer
  • Frequency of familial gastric cancer
  • The family cancer database.- II Genetics and Epigenetics
  • CDH1 gene, structure and function
  • E-cadherin germline mutation
  • Molecular mechanisms of hereditary diffuse gastric cancer initiation and progression
  • Germline missense mutants in hereditary diffuse gastric cancer
  • Alternative mechanisms to germline CDH1 mutations in hereditary diffuse gastric cancer
  • Beyond CDH1 mutation-causes of hereditary gastric cancer
  • Non-CDH1-associated familial gastric cancer and epigenetics factors.-III Pathology
  • Hereditary diffuse gastric cancer and lobular breast carcinoma
  • Pathology of hereditary diffuse gastric cancer.-IV Management
  • Clinical criteria for familial gastric cancer definition
  • Prophylactic total gastrectomy in CDH1 germline mutation carrier
  • Gastric cancer in other inherited syndromes
  • Clinical management of familial gastric cancer.- Appendix.- Index.