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20211014140600.0 |
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100427s2010 gw | s |||| 0|eng d |
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|a 9783642117923
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| 024 |
7 |
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|a 10.1007/978-3-642-11792-3
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 100 |
1 |
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|a Fernandez, Ariel.
|e author.
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| 245 |
1 |
0 |
|a Transformative Concepts for Drug Design: Target Wrapping /
|c by Ariel Fernandez.
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| 250 |
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|a 1st ed. 2010.
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| 260 |
# |
# |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2010.
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| 300 |
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|a X, 230 p. :
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 505 |
0 |
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|a Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy -- Wrapping Defects and the Architecture of Soluble Proteins -- Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins -- Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design -- Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation -- Evolution of Protein Wrapping and Implications for the Drug Designer -- Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence -- Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects -- Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways -- Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact -- Inducing Folding By Crating the Target -- Wrapper Drugs as Therapeutic Editors of Side Effects -- Wrapper Drugs for Personalized Medicine -- Last Frontier and Back to the Drawing Board: Protein–Water Interfacial Tension in Drug Design.
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| 650 |
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0 |
|a Biomedical engineering.
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| 650 |
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0 |
|a Medicinal chemistry.
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| 650 |
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0 |
|a Biophysics.
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| 650 |
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|a Biological physics.
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| 650 |
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|a Cancer research.
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| 650 |
1 |
4 |
|a Biomedical Engineering and Bioengineering.
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| 650 |
2 |
4 |
|a Medicinal Chemistry.
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| 650 |
2 |
4 |
|a Biological and Medical Physics, Biophysics.
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| 650 |
2 |
4 |
|a Cancer Research.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 900 |
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|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
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