Targeted Drug Strategies for Cancer and Inflammation /

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Jackman, Ann L. (Editor), Leamon, Christopher P. (Editor)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2011.
Edition:1st ed. 2011.
Subjects:
Table of Contents:
  • Biological Role, Properties and Therapeutic Applications of the Reduced Folate Carrier (RFC-SLC19A1) and the Proton-Coupled Folate Transporter (PCFT-SLC46A1)
  • Folate Receptors and Therapeutic Applications
  • Hormonal Control of Folate Receptor Genes
  • Folate Receptor Targeted Radionuclide Imaging Agents
  • Folate receptor targeted thymidylate synthase inhibitors
  • Discovery of novel antifolate inhibitors of de novo purine nucleotide biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry
  • Folate-receptor targeted cancer chemotherapy
  • Anti-FR antibody generation and engineering: development of new therapeutic tools
  • Folate Receptor Positive Macrophages: Cellular Targets for Imaging and Therapy of Inflammatory and Autoimmune Diseases
  • Targeting Activated Macrophages via a Functional Folate Receptor for Potential Treatment of Autoimmune/Inflammatory Disorders.-.