Translation and Its Regulation in Cancer Biology and Medicine /
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| Format: | eBook |
| Language: | English |
| Published: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2014.
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| Edition: | 1st ed. 2014. |
| Subjects: |
Table of Contents:
- Preface
- Introduction
- PART I. TRANSALATION MACHINERY IN CANCER
- Mechanism of Translation in Eukaryotes
- Diverse Mechanisms of Translation Regulation and Their Role in Cancer
- eIF4E and Its Binding Proteins
- RNA Helicases and Their Cofactors
- PDCD4
- eIF4G
- eIF3
- The eIF2 Complex and eIF2α
- eIF5A
- eIF6
- Translation Elongation
- Ribosomes
- Current and Emerging Therapies Targeting Translation
- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER
- mTOR and Regulation of Translation
- Ribosomal Protein S6 and S6 Kinases
- eIF4E Phosphorylation Downstream of MAPK Pathway
- PART III. CELL FATE AND TRANSLATION IN CANCER
- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells
- Translation and Apoptosis in Cancer
- Translation in Cancer at Hypoxia
- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES
- Melanoma and Non-Melanoma Skin Cancers
- Sarcomas
- Hematological Malignancies and Premalignant Conditions
- Brain Tumors
- Head and Neck Cancers
- Breast Cancer
- Cancers of the Respiratory System
- Gastric and Esophageal Cancers
- Colorectal Cancers
- Hepatic, Pancreatic and Biliary Cancers
- Pancreatic Neuroendocrine Tumors
- Gynecologic Cancers
- Prostate Cancer
- Cancers of the Urinary System
- List of Abbreviations.