|
|
|
|
| LEADER |
02726nam a22002895i 4500 |
| 001 |
000294585 |
| 005 |
20201019140856.0 |
| 007 |
cr nn 008mamaa |
| 008 |
180828s2018 xxu| s |||| 0|eng d |
| 020 |
|
|
|a 9781493987993
|
| 024 |
7 |
|
|a 10.1007/978-1-4939-8799-3
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
0 |
|a Zinc Finger Proteins :
|b Methods and Protocols /
|c edited by Jia Liu.
|
| 250 |
|
|
|a 1st ed. 2018.
|
| 260 |
# |
# |
|a New York, NY :
|b Springer New York :
|b Imprint: Humana,
|c 2018.
|
| 300 |
|
|
|a XII, 276 p. 59 illus., 44 illus. in color. :
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Methods in Molecular Biology,
|v 1867
|
| 505 |
0 |
|
|a Part 1. Basic Biology and Engineering of ZFPs -- PRDM14, a zinc finger protein, regulates cancer stemness -- Computational methods for analysis of the DNA-binding preferences of Cys2His2 zinc finger proteins -- Design and application of mA-specific Zinc finger proteins for the readout of DNA methylation -- Enhanced manipulation of human mitochondrial DNA heteroplasmy in vitro using tunable mtZFN technology -- Engineering RNA-binding proteins by modular assembly of RanBP2-type Zinc Fingers -- Design of a system for monitoring ubiquitination activities of E2 enzymes using engineered RING finger proteins -- Directed evolution of targeted recombinases for genome engineering -- Optical recording of cellular zinc dynamics with zinc finger based biosensors -- Delivery of superoxide dismutase using Cys2-His2 zinc-finger proteins -- Genome editing of MSCs as a platform for cell therapy -- Part 2. Methods for the Evaluation and Prevention of ZFN Cytotoxicity -- Integrated multimodal evaluation of genotoxicity in ZFN-modified primary human cells -- Selection and characterization of DNA aptamers against FokI nuclease domain -- An improved genome engineering method using surrogate reporter-coupled suicidal ZFNs -- Part 3. Delivery Methods of ZFPs -- Non-transgenic approach to deliver ZFNs in seeds for targeted genome engineering -- Gene editing in channel catfish via double electroporation of zinc finger nucleases -- Delivery of mtZFNs into early mouse embryos -- Stereotaxic surgery and viral-delivery of zinc finger epigenetic editing tools in rodent brain -- In-vivo applications of cell-penetrating zinc finger transcription factors -- Manufacturing and delivering genome-editing proteins.
|
| 650 |
|
0 |
|a Human genetics.
|
| 650 |
1 |
4 |
|a Human Genetics.
|
| 700 |
1 |
|
|a Liu, Jia.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 900 |
|
|
|a Libro descargado a ALEPH en bloque (proveniente de proveedor)
|