cGMP: Generators, Effectors and Therapeutic Implications /

Detalles Bibliográficos
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Schmidt, Harald H. H. W. (Editor ), Hofmann, Franz B. (Editor ), Stasch, Johannes-Peter. (Editor )
Formato: eBook
Lenguaje:English
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2009.
Edición:1st ed. 2009.
Colección:Handbook of Experimental Pharmacology, 191
Materias:
Tabla de Contenidos:
  • Basic Generators and Effectors
  • A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases
  • Biochemistry of Soluble Guanylate Cyclase
  • Genetic Mouse Models of the NO Receptor ‘Soluble’ Guanylyl Cyclases
  • Function and Dysfunction of Mammalian Membrane Guanylyl Cyclase Receptors: Lessons from Genetic Mouse Models and Implications for Human Diseases
  • Phosphodiesterases in the Central Nervous System
  • Structural and Biochemical Aspects of Tandem GAF Domains
  • Cyclic Nucleotide-Gated Channels
  • cGMP Regulated Protein Kinases (cGK)
  • cGK Substrates
  • Biochemical Detection of cGMP From Past to Present: An Overview
  • Novel Techniques for Real-Time Monitoring of cGMP in Living Cells
  • Pharmacology of cGMP
  • NO and sGC-Stimulating NO Donors
  • NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators
  • NO- and Haem-Independent Soluble Guanylate Cyclase Activators
  • Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications
  • Cyclic GMP-Hydrolyzing Phosphodiesterases
  • cGMP-Dependent Protein Kinase Modulators
  • cGMP-Dependent Protein Kinase as a Modifier of Behaviour
  • Clinical Applications
  • cGMP in the Vasculature
  • Modulating cGMP to Treat Lung Diseases
  • Modulation of cGMP in Heart Failure: A New Therapeutic Paradigm
  • Erectile Dysfunction and Lower Urinary Tract
  • cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells
  • cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour.