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04956nam a22003255i 4500 |
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978-1-4684-6247-0 |
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20191022041201.0 |
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cr nn 008mamaa |
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120303s1970 xxu| s |||| 0|eng d |
| 020 |
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|a 9781468462470
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| 024 |
7 |
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|a 10.1007/978-1-4684-6247-0
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 100 |
1 |
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|a Dertinger, Hermann.
|e author.
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| 245 |
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|a Molecular Radiation Biology
|b The Action of Ionizing Radiation on Elementary Biological Objects /
|c by Hermann Dertinger, Horst Jung.
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| 250 |
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|a 1st ed. 1970.
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| 260 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 1970.
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| 300 |
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|a X, 238 p. 1 illus.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Heidelberg Science Library,
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| 505 |
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|a 1. Introduction -- 1.1. Historical Survey -- 1.2. Dose-Response Curves and Special Aspects of Radiation Action -- 1.3. The Temporal Stages of Radiation Action -- 1.4. The Significance of Molecular Radiation Biology -- 1.5. An Introduction to Molecular Radiation Biology -- References -- 2. The Hit Theory -- 2.1. Basic Concepts -- 2.2. Single and Multiple Hit Phenomena -- 2.3. Dose-Response Curves of Multiple Target Systems -- 2.4. The Influence of Biological Variability on the Form of Dose-Response Curves -- 2.5. The “Relative Steepness” of the Dose-Response Curve -- 2.6. Possibilities of Deception by Single-Hit Curves -- References -- 3. The Stochastics of the Action of Radiation -- 3.1. Kinetic Interpretation of the Dose-Response Curve -- 3.2. Multi-Hit Curves -- 3.3. Reverse Processes -- 3.4. A Formalistic Description of Dose-Response Curves -- 3.5. Dose-Response Curves of Colony Formation -- References -- 4. Primary Processes of Energy Absorption -- 4.1. X- and Gamma-Radiation -- 4.2. Neutrons -- 4.3. Charged Particles -- 4.4. Uptake of Energy by Molecules -- 4.5. The Energy Distribution of Secondary Electrons -- 4.6. Energy Deposited per Primary Interaction -- References -- 5. Target Theory and Action Cross Section -- 5.1. Establishment of a Rigid Concept of a “Hit” -- 5.2. Target Theory -- 5.3. Theory of the Action Cross Section -- 5.4. Relative Biological Effectiveness -- References -- 6. Direct and Indirect Action of Radiation -- 6.1. The Direct Effect -- 6.2. Indirect Effect in Solutions -- 6.3. Indirect Effect in Cells -- 6.4. Indirect Effect in the Dry State -- 6.5. Protective and Sensitizing Agents -- References -- 7. The Temperature Effect -- 7.1. Experimental Observations -- 7.2. Temperature Effect and the Indirect Action of Radiation. -- 7.3. LET-Dependence of the Temperature Effect -- 7.4. The “Thermal Spike” Model -- References -- 8. The Oxygen Effect -- 8.1. The Oxygen Effect in Macromolecules -- 8.2. An Oxygen Effect Hypothesis -- 8.3. The Oxygen Effect in Bacteria -- 8.4. Oxygen Effect and LET -- References -- 9. The Action of Radiation on Enzymes: The Example of Ribonuclease -- 9.1. Structure and Function of Ribonuclease -- 9.2. Inactivation Kinetics -- 9.3. Radiation-Induced Radicals -- 9.4. Changes in Irradiated Enzyme Molecules -- 9.5. Separation and Identification of Irradiation Products -- 9.6. Amino Acid Analysis -- 9.7. Mechanisms of Inactivation -- References -- 10. Physico-Chemical Changes in Irradiated Nucleic Acids -- 10.1. The Structure of DNA -- 10.2. Radiation-Induced Radicals -- 10.3. Chemical Changes in Irradiated DNA -- 10.4. Breaks in the Polynucleotide Chains -- 10.5. Intermolecular Cross-Linking -- 10.6. Rupture of Hydrogen Bonds -- References -- 11. Inactivation of Nucleic Acid Functions -- 11.1. Functions of Nucleic Acids -- 11.2. Infectivity -- 11.3. Transformation -- 11.4. Priming Activity of DNA -- 11.5. Enzyme Induction -- 11.6. DNA-mRNA Hybrids -- 11.7. Translation -- References -- 12. The Action of Radiation on Viruses -- 12.1. Basic Properties of Viruses -- 12.2. Inactivation of Viruses containing Single-Stranded Nucleic Acids -- 12.3. Inactivation of Viruses containing Double-Stranded DNA -- 12.4. Repair of Radiation Damage in Viral DNA -- 12.5. BU Effect -- References -- 13. The Action of Radiation on Bacteria -- 13.1. Some Basic Properties of Bacteria -- 13.2. Inactivation of Bacteria -- 13.3. Bacterial DNA as the Critical Target -- 13.4. Repair of UV Damage -- 13.5. Repair of Damage caused by Ionizing Radiation -- 13.6. Genetic Control of Repair in Bacterium E. coli -- 13.7. Micrococcus Radiodurans -- References -- 14. Radiation Sensitivity and Biological Complexity -- 14.1. Attempts at a Systematic Approach -- 14.2. What is Radiation Sensitivity? -- References.
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| 650 |
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|a Life sciences.
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| 650 |
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|a Medicine.
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| 650 |
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4 |
|a Life Sciences, general.
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| 650 |
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|a Biomedicine, general.
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| 700 |
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|a Jung, Horst.
|e author.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-1-4684-6247-0
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