Molecular Radiation Biology The Action of Ionizing Radiation on Elementary Biological Objects /
| Autores principales: | , |
|---|---|
| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer New York : Imprint: Springer,
1970.
|
| Edición: | 1st ed. 1970. |
| Colección: | Heidelberg Science Library,
|
| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-1-4684-6247-0 |
Tabla de Contenidos:
- 1. Introduction
- 1.1. Historical Survey
- 1.2. Dose-Response Curves and Special Aspects of Radiation Action
- 1.3. The Temporal Stages of Radiation Action
- 1.4. The Significance of Molecular Radiation Biology
- 1.5. An Introduction to Molecular Radiation Biology
- References
- 2. The Hit Theory
- 2.1. Basic Concepts
- 2.2. Single and Multiple Hit Phenomena
- 2.3. Dose-Response Curves of Multiple Target Systems
- 2.4. The Influence of Biological Variability on the Form of Dose-Response Curves
- 2.5. The “Relative Steepness” of the Dose-Response Curve
- 2.6. Possibilities of Deception by Single-Hit Curves
- References
- 3. The Stochastics of the Action of Radiation
- 3.1. Kinetic Interpretation of the Dose-Response Curve
- 3.2. Multi-Hit Curves
- 3.3. Reverse Processes
- 3.4. A Formalistic Description of Dose-Response Curves
- 3.5. Dose-Response Curves of Colony Formation
- References
- 4. Primary Processes of Energy Absorption
- 4.1. X- and Gamma-Radiation
- 4.2. Neutrons
- 4.3. Charged Particles
- 4.4. Uptake of Energy by Molecules
- 4.5. The Energy Distribution of Secondary Electrons
- 4.6. Energy Deposited per Primary Interaction
- References
- 5. Target Theory and Action Cross Section
- 5.1. Establishment of a Rigid Concept of a “Hit”
- 5.2. Target Theory
- 5.3. Theory of the Action Cross Section
- 5.4. Relative Biological Effectiveness
- References
- 6. Direct and Indirect Action of Radiation
- 6.1. The Direct Effect
- 6.2. Indirect Effect in Solutions
- 6.3. Indirect Effect in Cells
- 6.4. Indirect Effect in the Dry State
- 6.5. Protective and Sensitizing Agents
- References
- 7. The Temperature Effect
- 7.1. Experimental Observations
- 7.2. Temperature Effect and the Indirect Action of Radiation.
- 7.3. LET-Dependence of the Temperature Effect
- 7.4. The “Thermal Spike” Model
- References
- 8. The Oxygen Effect
- 8.1. The Oxygen Effect in Macromolecules
- 8.2. An Oxygen Effect Hypothesis
- 8.3. The Oxygen Effect in Bacteria
- 8.4. Oxygen Effect and LET
- References
- 9. The Action of Radiation on Enzymes: The Example of Ribonuclease
- 9.1. Structure and Function of Ribonuclease
- 9.2. Inactivation Kinetics
- 9.3. Radiation-Induced Radicals
- 9.4. Changes in Irradiated Enzyme Molecules
- 9.5. Separation and Identification of Irradiation Products
- 9.6. Amino Acid Analysis
- 9.7. Mechanisms of Inactivation
- References
- 10. Physico-Chemical Changes in Irradiated Nucleic Acids
- 10.1. The Structure of DNA
- 10.2. Radiation-Induced Radicals
- 10.3. Chemical Changes in Irradiated DNA
- 10.4. Breaks in the Polynucleotide Chains
- 10.5. Intermolecular Cross-Linking
- 10.6. Rupture of Hydrogen Bonds
- References
- 11. Inactivation of Nucleic Acid Functions
- 11.1. Functions of Nucleic Acids
- 11.2. Infectivity
- 11.3. Transformation
- 11.4. Priming Activity of DNA
- 11.5. Enzyme Induction
- 11.6. DNA-mRNA Hybrids
- 11.7. Translation
- References
- 12. The Action of Radiation on Viruses
- 12.1. Basic Properties of Viruses
- 12.2. Inactivation of Viruses containing Single-Stranded Nucleic Acids
- 12.3. Inactivation of Viruses containing Double-Stranded DNA
- 12.4. Repair of Radiation Damage in Viral DNA
- 12.5. BU Effect
- References
- 13. The Action of Radiation on Bacteria
- 13.1. Some Basic Properties of Bacteria
- 13.2. Inactivation of Bacteria
- 13.3. Bacterial DNA as the Critical Target
- 13.4. Repair of UV Damage
- 13.5. Repair of Damage caused by Ionizing Radiation
- 13.6. Genetic Control of Repair in Bacterium E. coli
- 13.7. Micrococcus Radiodurans
- References
- 14. Radiation Sensitivity and Biological Complexity
- 14.1. Attempts at a Systematic Approach
- 14.2. What is Radiation Sensitivity?
- References.