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02345nam a22002895i 4500 |
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978-1-4684-8332-1 |
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20191029011249.0 |
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cr nn 008mamaa |
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121227s1980 xxu| s |||| 0|eng d |
| 020 |
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|a 9781468483321
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|a 10.1007/978-1-4684-8332-1
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 100 |
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|a Barlow, R.B.
|e author.
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|a Quantitative Aspects of Chemical Pharmacology
|b Chemical Ideas in Drug Action with Numerical Examples /
|c by R.B. Barlow.
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| 250 |
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|a 1st ed. 1980.
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| 260 |
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|a New York, NY :
|b Springer US :
|b Imprint: Springer,
|c 1980.
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| 300 |
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|a VI, 250 p.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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|a 1. Measuring Drug Activity -- Measuring the Effects of Drugs: ‘Responses’ -- Assessing Biological Activity -- Application of Bioassay Methods to the Comparison of Drugs -- Types of Drug Action -- 2. Physicochemical Problems -- Rates of Reaction and Positions of Equilibrium -- Solubility -- Volume of Dilution -- Rate of Removal -- Rate of Absorption -- Partition Coefficients and Crossing Membranes -- Relations between Reaction Rates and Equilibrium Constants -- 3. The Size and Shape of Molecules -- Size: Molal Volumes and Apparent Molal Volumes -- Shape -- Isomerism -- Optical Rotation -- Stereochemical Purity and Biological Activity -- Description of the Arrangements of Groups about an Asymmetric Carbon Atom -- Preferred Conformations -- 4. Chemical Processes where Size and Shape are Important -- Adsorption -- Adsorption of Two Species -- Enzyme and Substrate -- The Need for Other Models -- Agonists and Receptors -- Rate Theory -- Desensitisation of Receptors -- Forces between Drug and Receptor -- 5. The Prediction of Drug Activity -- Nonspecific Activity -- Homologous Series -- Biological Activity and Chemical Properties: the Ideas of Hansch -- Is Affinity Predictable? -- Conclusion -- Appendix: Line-fitting by the method of least-squares -- Answers to Examples.
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| 650 |
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|a Pharmacology.
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| 650 |
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|a Pharmacology/Toxicology.
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| 650 |
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|a Science, Humanities and Social Sciences, multidisciplinary.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-1-4684-8332-1
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